Sandri Marco
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Physiology (Bethesda). 2008 Jun;23:160-70. doi: 10.1152/physiol.00041.2007.
Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutrients, and growth factors. Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases.
肌肉性能受收缩蛋白周转的影响。新肌原纤维的产生和现有蛋白质的降解是一种微妙的平衡，根据具体情况，这种平衡可促进肌肉生长或流失。蛋白质合成和蛋白质降解由受机械应力、身体活动、营养物质可用性和生长因子影响的途径协同调节。了解调节肌肉质量的信号传导可能为预防和治疗代谢性和神经肌肉疾病中的肌肉萎缩提供潜在的治疗靶点。
