Furugen R, Hayashida H, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H, Saito T
Department of Oral Health, Unit of Social Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Periodontal Res. 2008 Oct;43(5):556-62. doi: 10.1111/j.1600-0765.2008.01085.x. Epub 2008 Jun 28.
Diabetes and periodontitis are associated with each other. Adipokines, specifically adiponectin and resistin, are secreted from adipocytes and are thought to cause insulin resistance in rodents. Additionally, adiponectin and resistin may play a role in inflammation and immune responses. The aim of this study was to clarify the relationship between serum levels of adipokines and periodontal conditions in elderly Japanese people with and without periodontitis.
A total of 158 Japanese men and women (76 years old) with or without periodontitis were selected for the study. Serum adiponectin, resistin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) concentrations were compared between subjects with and without periodontitis.
Serum resistin levels and total leukocyte counts in subjects with periodontitis were higher than in control subjects. No significant differences were observed in adiponectin, IL-6 and TNF-alpha levels between subjects with and without periodontitis. Logistic regression analysis showed that periodontitis with at least one tooth that displayed a probing pocket depth of > or =6 mm was significantly associated with higher serum resistin levels (odds ratio, 2.0; 95% confidence interval, 1.0-4.0). When excluding periodontitis subjects with < or =10% of bleeding on probing and excluding control subjects with >10% bleeding on probing, differences between groups and odds ratio increased. Serum adiponectin tended to decrease in patients with periodontitis, albeit not significantly.
Increased serum resistin levels were significantly associated with periodontal condition, especially when considering bleeding on probing, in elderly Japanese people. There was also a trend, though non-significant, toward decreased levels of adiponectin in subjects with periodontitis.
糖尿病与牙周炎相互关联。脂肪因子，特别是脂联素和抵抗素，由脂肪细胞分泌，被认为会导致啮齿动物出现胰岛素抵抗。此外，脂联素和抵抗素可能在炎症和免疫反应中发挥作用。本研究的目的是阐明在患有和未患有牙周炎的日本老年人中，血清脂肪因子水平与牙周状况之间的关系。
共选取158名76岁患有或未患有牙周炎的日本男性和女性进行研究。比较了患有和未患有牙周炎的受试者血清脂联素、抵抗素、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的浓度。
患有牙周炎的受试者血清抵抗素水平和白细胞总数高于对照组。患有和未患有牙周炎的受试者在脂联素、IL-6和TNF-α水平上未观察到显著差异。逻辑回归分析显示，至少有一颗牙齿探诊袋深度≥6mm的牙周炎与较高的血清抵抗素水平显著相关（比值比，2.0；95%置信区间，1.0 - 4.0）。当排除探诊出血≤10%的牙周炎受试者以及排除探诊出血>10%的对照受试者时，组间差异和比值比增加。牙周炎患者血清脂联素虽无显著下降，但有下降趋势。
在日本老年人中，血清抵抗素水平升高与牙周状况显著相关，尤其是在考虑探诊出血时。牙周炎患者的脂联素水平也有下降趋势，尽管不显著。
