• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

慢性牙周炎患者治疗前后龈沟液中脂联素和抵抗素水平的评估：一项临床生化研究

Evaluation of Adiponectin and Resistin Levels in Gingival Crevicular Fluid in Patients with Chronic Periodontitis Before and After Treatment: A Clinico-Biochemical Study.

作者信息

Fairlin P, Raja S A Jacob, James Johnson Raja, Kumar Tamil Selvan, Shankar Ravi, Divya S

机构信息

Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India.

出版信息

J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1178-S1183. doi: 10.4103/jpbs.jpbs_318_21. Epub 2021 Nov 10.

DOI:10.4103/jpbs.jpbs_318_21
PMID:35017952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8687019/
Abstract

AIM

The aim of this study was to find out the association of adiponectin and resistin levels in gingival crevicular fluid (GCF) with the clinical parameters before and after scaling and root planing in periodontitis patients.

METHODS

A total of 50 patients were recruited from the Outpatient Department of Periodontics, JKK Nattraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India. The protocol was reviewed and approved by the institutional ethical board. Informed consent was obtained from the patients and the study-related procedures were explained. Patients were divided into two groups. Group I (25 patients) consisted of healthy patients. Group II (25 patients) consisted of periodontitis patients. The periodontitis patients after treatment were considered as Group III. GCF samples were collected before treatment and 21 days after treatment. The levels of adiponectin and resistin were evaluated using Immunotag™ Human RETN enzyme-linked immunosorbent assay (ELISA) kit (ITEH0269) and Immunotag™ Human ADP (adiponectin) ELISA kit (ITEH2593). The levels were correlated with the clinical parameters.

RESULTS

There were an increase in the mean adiponectin level and a decrease in the mean resistin level at the end of periodontal therapy.

CONCLUSIONS

Adiponectin which is an anti-inflammatory component was found to increase after periodontal therapy, and resistin which is an inflammatory component has been decreased after periodontal therapy.

摘要

目的

本研究旨在探讨牙周炎患者龈沟液（GCF）中脂联素和抵抗素水平与龈上洁治和根面平整治疗前后临床参数的相关性。

方法

从印度泰米尔纳德邦科马勒帕莱亚马JKK那罗延牙科医学院和医院牙周病门诊招募了50名患者。该方案经机构伦理委员会审查并批准。获得了患者的知情同意，并对与研究相关的程序进行了解释。患者分为两组。第一组（25名患者）为健康患者。第二组（25名患者）为牙周炎患者。治疗后的牙周炎患者被视为第三组。在治疗前和治疗后21天收集GCF样本。使用Immunotag™人RETN酶联免疫吸附测定（ELISA）试剂盒（ITEH0269）和Immunotag™人ADP（脂联素）ELISA试剂盒（ITEH2593）评估脂联素和抵抗素水平。这些水平与临床参数相关。

结果

牙周治疗结束时，平均脂联素水平升高，平均抵抗素水平降低。

结论

发现作为抗炎成分的脂联素在牙周治疗后增加，而作为炎症成分的抵抗素在牙周治疗后减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/c110495ca133/JPBS-13-1178-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/0d2f6e6cf626/JPBS-13-1178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/90b0373064d9/JPBS-13-1178-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/ee7d2037de65/JPBS-13-1178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/83a763a31d11/JPBS-13-1178-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/c110495ca133/JPBS-13-1178-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/0d2f6e6cf626/JPBS-13-1178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/90b0373064d9/JPBS-13-1178-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/ee7d2037de65/JPBS-13-1178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/83a763a31d11/JPBS-13-1178-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d172/8687019/c110495ca133/JPBS-13-1178-g005.jpg

相似文献

1
Evaluation of Adiponectin and Resistin Levels in Gingival Crevicular Fluid in Patients with Chronic Periodontitis Before and After Treatment: A Clinico-Biochemical Study.慢性牙周炎患者治疗前后龈沟液中脂联素和抵抗素水平的评估：一项临床生化研究
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1178-S1183. doi: 10.4103/jpbs.jpbs_318_21. Epub 2021 Nov 10.
2
Gingival crevicular fluid resistin levels in chronic periodontitis with type 2 diabetes before and after non-surgical periodontal therapy: A clinico-biochemical study.2型糖尿病伴慢性牙周炎患者非手术牙周治疗前后龈沟液抵抗素水平：一项临床生化研究
Indian J Dent Res. 2019 Jan-Feb;30(1):47-51. doi: 10.4103/ijdr.IJDR_215_17.
3
Relevance of single-nucleotide polymorphism to the expression of resistin gene affecting serum and gingival crevicular fluid resistin levels in chronic periodontitis and type 2 diabetes mellitus: A randomized control clinical trial.单核苷酸多态性与抵抗素基因表达的相关性对慢性牙周炎和2型糖尿病患者血清及龈沟液抵抗素水平的影响：一项随机对照临床试验
J Indian Soc Periodontol. 2019 Mar-Apr;23(2):131-136. doi: 10.4103/jisp.jisp_361_18.
4
Effect of scaling and root planing on interleukin-1β, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients.龈下刮治和根面平整对慢性牙周炎患者龈沟液中白细胞介素-1β、白细胞介素-8 和基质金属蛋白酶-8 水平的影响。
J Periodontal Res. 2012 Dec;47(6):681-8. doi: 10.1111/j.1600-0765.2012.01480.x. Epub 2012 Apr 18.
5
Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up.牙周治疗后肥胖患者体内脂肪因子的局部和血清水平：一年随访
J Clin Periodontol. 2015 May;42(5):431-9. doi: 10.1111/jcpe.12396. Epub 2015 Apr 30.
6
Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at -420.血清和龈沟液中的抵抗素作为牙周炎症的标志物及其与人类抵抗素基因-420位点单核苷酸多态性的相关性
Contemp Clin Dent. 2013 Apr;4(2):192-7. doi: 10.4103/0976-237X.114878.
7
Gingival crevicular fluid osteopontin levels in periodontal health and disease.牙周健康与疾病状态下龈沟液中骨桥蛋白的水平
J Periodontol. 2006 Oct;77(10):1674-80. doi: 10.1902/jop.2006.060016.
8
The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment on gingival crevicular fluid levels of transforming growth factor-beta 1, tissue plasminogen activator and plasminogen activator inhibitor 1 in smoking and non-smoking chronic periodontitis patients: A split-mouth, randomized control study.低水平激光疗法作为非手术牙周治疗的辅助手段对吸烟和非吸烟慢性牙周炎患者龈沟液中转化生长因子-β1、组织纤溶酶原激活物和纤溶酶原激活物抑制剂 1 水平的影响：一项分口、随机对照研究。
J Periodontal Res. 2017 Oct;52(5):872-882. doi: 10.1111/jre.12457. Epub 2017 Apr 10.
9
Gingival crevicular fluid and serum levels of resistin in obese and non-obese subjects with and without periodontitis and association with single nucleotide polymorphism at -420.肥胖和非肥胖且患有和未患有牙周炎的受试者的龈沟液和血清抵抗素水平及其与-420处单核苷酸多态性的关联
J Indian Soc Periodontol. 2014 Sep;18(5):555-9. doi: 10.4103/0972-124X.142438.
10
Adjunctive subantimicrobial dose doxycycline: effect on clinical parameters and gingival crevicular fluid transforming growth factor-beta levels in severe, generalized chronic periodontitis.辅助性亚抗菌剂量强力霉素：对重度广泛性慢性牙周炎临床参数及龈沟液转化生长因子-β水平的影响
J Clin Periodontol. 2005 Mar;32(3):244-53. doi: 10.1111/j.1600-051X.2005.00663.x.

引用本文的文献

1
Effects of non-surgical periodontal therapy on gingival crevicular fluid CTRP-1, TNF-α, and IL-10 levels.非手术牙周治疗对龈沟液中CTRP-1、TNF-α和IL-10水平的影响。
Clin Oral Investig. 2025 Jun 21;29(7):345. doi: 10.1007/s00784-025-06420-3.

本文引用的文献

1
Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis.非手术牙周治疗对慢性牙周炎肥胖和正常体重个体血浆活性氧代谢产物、龈沟液抵抗素及血清抵抗素水平的影响。
J Indian Soc Periodontol. 2018 Jul-Aug;22(4):310-316. doi: 10.4103/jisp.jisp_108_18.
2
Effect of periodontal treatment on adipokines in type 2 diabetes.牙周治疗对2型糖尿病患者脂肪因子的影响。
World J Diabetes. 2014 Dec 15;5(6):924-31. doi: 10.4239/wjd.v5.i6.924.
3
Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at -420.
血清和龈沟液中的抵抗素作为牙周炎症的标志物及其与人类抵抗素基因-420位点单核苷酸多态性的相关性
Contemp Clin Dent. 2013 Apr;4(2):192-7. doi: 10.4103/0976-237X.114878.
4
Inflammatory mediators in the pathogenesis of periodontitis.牙周炎发病机制中的炎症介质。
Expert Rev Mol Med. 2013 Aug 5;15:e7. doi: 10.1017/erm.2013.8.
5
The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese.日本老年人牙周状况与血清抵抗素和脂联素水平之间的关系。
J Periodontal Res. 2008 Oct;43(5):556-62. doi: 10.1111/j.1600-0765.2008.01085.x. Epub 2008 Jun 28.
6
Serum levels of resistin and adiponectin in women with periodontitis: the Hisayama study.牙周炎女性血清抵抗素和脂联素水平：久山研究
J Dent Res. 2008 Apr;87(4):319-22. doi: 10.1177/154405910808700416.
7
The emerging role of adipokines as mediators of inflammation and immune responses.脂肪因子作为炎症和免疫反应介质的新作用。
Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):313-25. doi: 10.1016/j.cytogfr.2007.04.007. Epub 2007 May 15.
8
Adipocytokines: mediators linking adipose tissue, inflammation and immunity.脂肪细胞因子：连接脂肪组织、炎症与免疫的介质
Nat Rev Immunol. 2006 Oct;6(10):772-83. doi: 10.1038/nri1937. Epub 2006 Sep 22.
9
Resistin, an adipokine with potent proinflammatory properties.抵抗素，一种具有强大促炎特性的脂肪因子。
J Immunol. 2005 May 1;174(9):5789-95. doi: 10.4049/jimmunol.174.9.5789.