本实验室对血红蛋白和酶进行的纳米生物技术修饰。
Nanobiotechnological modification of hemoglobin and enzymes from this laboratory.
作者信息
Chang Thomas Ming Swi
机构信息
Artificial Cells & Organs Research Centre of the Departments of Physiology, Medicine & Biomedical Engineering, Faculty of Medicine, McGill University, 3655, Drummond Street, Montreal, Quebec, Canada H3G 1Y6.
出版信息
Biochim Biophys Acta. 2008 Oct;1784(10):1435-40. doi: 10.1016/j.bbapap.2008.05.006. Epub 2008 Jun 17.
Abstract
Polyhemoglobin is formed by the nanobiotechnological assembling of hemoglobin molecules into soluble nanodimension complex. A further step involves the nanobiotechnological assembly of hemoglobin, catalase and superoxide dismutase into a soluble nanodimension complex. This acts both as oxygen carrier and antioxidant to prevent the oxidative effects of hemoglobin. A further step is the preparation of nanodimension artificial red blood cells that contain hemoglobin and all the enzymes present in red blood cells. Other approaches include a polyhemoglobin-fibrinogen that acts as an oxygen carrier with platelet-like activity, and a polyhemoglobin-tyrosinase to retard the growth of a fatal skin cancer, melanoma.
摘要
多聚血红蛋白是通过血红蛋白分子的纳米生物技术组装形成可溶性纳米尺寸复合物。进一步的步骤是将血红蛋白、过氧化氢酶和超氧化物歧化酶进行纳米生物技术组装成可溶性纳米尺寸复合物。这既作为氧载体又作为抗氧化剂来防止血红蛋白的氧化作用。更进一步的步骤是制备含有血红蛋白和红细胞中所有酶的纳米尺寸人工红细胞。其他方法包括具有血小板样活性的作为氧载体的多聚血红蛋白 - 纤维蛋白原，以及用于延缓致命皮肤癌黑色素瘤生长的多聚血红蛋白 - 酪氨酸酶。
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Synthesis of a hemoglobin polymer containing antioxidant enzymes using complementary chemistry of maleimides and sulfhydryls.利用马来酰亚胺和巯基的互补化学合成含抗氧化酶的血红蛋白聚合物。
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