Amsterdam Jay D, Newberg Andrew B
Department of Psychiatry, The Depression Research Unit, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Neuropsychobiology. 2007;55(3-4):167-70. doi: 10.1159/000106476. Epub 2007 Jul 26.
We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients.
[(99m)Tc]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [(99m)Tc]TRODAT-1 binding affinity was calculated for regions of interest in the striatum.
Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05).
These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding.
我们检测了双相抑郁和单相抑郁患者纹状体多巴胺转运体（DAT）的结合情况，并使用选择性DAT放射性配体[（99m）Tc]TRODAT-1和单光子发射计算机断层扫描成像，将这些值与健康对照者的值进行比较。我们假设双相患者的DAT水平可能高于单相患者。
对5例双相患者、10例单相患者和46例健康对照者进行[（99m）Tc]TRODAT-1扫描。计算纹状体感兴趣区域的[（99m）Tc]TRODAT-1结合亲和力的分布体积比（DVR）。
双相患者右侧后壳核（p = 0.001）和左侧尾状核区域（p = 0.007）的DVR值高于对照组。与对照组相比，双相患者在所有检测脑区的DAT结合均略低，且右侧尾状核区域的DVR显著低于单相患者（p = 0.05）。
这些数据表明，与对照组相比，双相抑郁和单相抑郁患者纹状体DAT密度可能增加，且双相抑郁和单相抑郁患者可能具有不同的纹状体DAT结合模式。
