Kang Hahk-Soo, Kim Kyoung-Rok, Jun Eun-Mi, Park Soon-Hye, Lee Tae-Soo, Suh Joo-Won, Kim Jong-Pyung
Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea.
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4047-50. doi: 10.1016/j.bmcl.2008.05.110. Epub 2008 Jun 3.
Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS(+), DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe(2+)/H(2)O(2)-induced breakage.
从粪生黑蛋巢菌的菌丝体培养物中分离出三种新的聚酮化合物，即黑蛋巢菌素A（1）、B（2）和C（3）。根据核磁共振和质谱数据阐明了这些化合物的结构。通过对ABTS(+)、DPPH和超氧阴离子自由基的清除能力评估了这些化合物的抗氧化活性。黑蛋巢菌素A-C表现出与参考抗氧化剂丁基羟基茴香醚（BHA）和Trolox相当的显著抗氧化活性。黑蛋巢菌素A-C保护超螺旋质粒DNA免受Fe(2+)/H(2)O(2)诱导的断裂。
