Yamauchi Motoo, Ocak Hasan, Dostal Jesse, Jacono Frank J, Loparo Kenneth A, Strohl Kingman P
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, USA.
Respir Physiol Neurobiol. 2008 Jul 31;162(2):117-25. doi: 10.1016/j.resp.2008.05.003. Epub 2008 May 15.
The purpose was to examine sighs and spontaneous pauses in regard to the stability of resting breathing in the B6 strain, compared to the A/J strain. A 5-HT1A receptor agonist (buspirone) and a chromosomal substitution strain (B6a1) were used to further alter breathing patterning. Ten-minute recordings of room air breathing were collected from unanaesthetized B6, A/J, and B6a1 mice. Despite no differences between strains in the magnitude and incidence of sighs, post-sigh apneas, the variation for duration of expiration (Te) after sighs, and the number of spontaneous pauses were greater in the B6, while Shannon Entropy (nonlinear metrics) for Te after sighs was lower in B6, compared to the other strains. Buspirone and chromosomal substitution eliminated post-sigh apneas and decreased spontaneous pauses. A greater irregularity and the lower complexity of post-sigh breathing in B6 are reversed by elements on A/J chromosome 1 and by increased 5-HT1A serotonergic tone.
目的是研究与A/J品系相比，B6品系静息呼吸稳定性方面的叹息和自发停顿情况。使用5-羟色胺1A受体激动剂（丁螺环酮）和染色体置换品系（B6a1）进一步改变呼吸模式。从未麻醉的B6、A/J和B6a1小鼠收集10分钟的室内空气呼吸记录。尽管各品系在叹息的幅度和发生率、叹息后呼吸暂停、叹息后呼气持续时间（Te）的变化以及自发停顿次数方面没有差异，但与其他品系相比，B6品系中Te的香农熵（非线性指标）更低，而叹息后Te的变化以及自发停顿次数在B6品系中更大。丁螺环酮和染色体置换消除了叹息后呼吸暂停并减少了自发停顿。A/J染色体1上的元件以及5-羟色胺1A血清素能张力的增加逆转了B6品系中叹息后呼吸更大的不规则性和更低的复杂性。
