Ehlert K A, Beumer C W E, Groot M C E
TNO Quality of Life, Zeist, The Netherlands.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):904-10. doi: 10.1080/02652030701867867.
A comprehensive migration database was established for bisphenol A from polycarbonate baby bottles into water during exposure to microwave heating. Eighteen different brands of polycarbonate baby bottles sold in Europe were collected. Initial residual content of bisphenol A and migration after microwave heating were determined. Residual content of bisphenol A in the polycarbonate baby bottles ranged from 1.4 to 35.3 mg kg(-1). Migration of bisphenol A was determined by placing a polycarbonate bottle filled with water in a microwave oven and heating to 100 degrees C; the level of bisphenol A in the water was analysed by GC-MS. The procedure of microwave heating and analysis was repeated twice for the same bottle and, thus, three migration extracts were prepared for each test specimen. Migration of bisphenol A into water ranged from <0.1 to 0.7 microg l(-1). There was no correlation between the amount of residual content of bisphenol A in the bottles and the migration of bisphenol A into water. Furthermore, there was no correlation between the amounts of bisphenol A in consecutive migration extracts. Data show that during three microwave-heating cycles of a baby bottle made from polycarbonate, microwave radiation had no effect on the migration of bisphenol A into water from polycarbonate. All levels found were well below the specific migration limit of 0.6 mg kg(-1) specified for bisphenol A in Commission Directive 2004/19/EC.
建立了一个综合迁移数据库，用于研究聚碳酸酯婴儿奶瓶在微波加热过程中双酚A向水中的迁移情况。收集了欧洲市场上销售的18个不同品牌的聚碳酸酯婴儿奶瓶。测定了双酚A的初始残留量以及微波加热后的迁移量。聚碳酸酯婴儿奶瓶中双酚A的残留量在1.4至35.3 mg kg⁻¹之间。通过将装满水的聚碳酸酯奶瓶放入微波炉中加热至100℃来测定双酚A的迁移情况；水中双酚A的含量通过气相色谱 - 质谱联用仪（GC - MS）进行分析。对同一奶瓶重复进行两次微波加热和分析过程，因此每个测试样品制备了三份迁移提取物。双酚A向水中的迁移量在<0.1至0.7 μg l⁻¹之间。奶瓶中双酚A的残留量与双酚A向水中的迁移量之间没有相关性。此外，连续迁移提取物中双酚A的含量之间也没有相关性。数据表明，在聚碳酸酯婴儿奶瓶的三个微波加热循环过程中，微波辐射对双酚A从聚碳酸酯向水中的迁移没有影响。所有检测到的含量均远低于欧盟委员会指令2004/19/EC中规定的双酚A特定迁移限量0.6 mg kg⁻¹。
