Biomonitoring laboratory, Exposure and Biomonitoring Division, Chemicals Management Directorate, Health Canada, Ottawa, Canada.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jun;26(6):928-37. doi: 10.1080/02652030802706725.
Human exposure to bisphenol A (BPA) has recently received special attention. It has been shown that exposure to BPA may occur through the consumption of beverages or foods that have been in contact with polycarbonate (PC) plastic containers or epoxy resins in food packaging. A BPA migration study was conducted using a variety of plastic containers, including polycarbonate baby bottles, non-PC baby bottles, baby bottle liners, and reusable PC drinking bottles. Water was used to simulate migration into aqueous and acidic foods; 10% ethanol solution to simulate migration to low- and high-alcoholic foods; and 50% ethanol solution to simulate migration to fatty foods. By combining solid-phase extraction, BPA derivatization and analysis by GC-EI/MS/MS, a very low detection limit at the ng l(-1) level was obtained. Migration of BPA at 40 degrees C ranged from 0.11 microg l(-1) in water incubated for 8 h to 2.39 microg l(-1) in 50% ethanol incubated for 240 h. Residual BPA leaching from PC bottles increased with temperature and incubation time. In comparison with the migration observed from PC bottles, non-PC baby bottles and baby bottle liners showed only trace levels of BPA. Tests for leachable lead and cadmium were also conducted on glass baby bottles since these represent a potential alternative to plastic bottles. No detectable lead or cadmium was found to leach from the glass. This study indicated that non-PC plastic baby bottles, baby bottle liners and glass baby bottles might be good alternatives for polycarbonate bottles.
人类接触双酚 A（BPA）最近受到特别关注。研究表明，人类可能通过摄入与聚碳酸酯（PC）塑料容器或食品包装中的环氧树脂接触过的饮料或食物而接触 BPA。本研究采用多种塑料容器（包括聚碳酸酯婴儿奶瓶、非 PC 婴儿奶瓶、奶瓶衬垫和可重复使用的 PC 饮水瓶）进行 BPA 迁移研究。水用于模拟向水性和酸性食品中的迁移；10%乙醇溶液用于模拟向低酒精和高酒精食品中的迁移；50%乙醇溶液用于模拟向高脂肪食品中的迁移。通过固相萃取、BPA 衍生化和 GC-EI/MS/MS 分析，在 ng l(-1) 水平上获得了非常低的检测限。40°C 时，BPA 的迁移范围从水中孵育 8 小时的 0.11μg l(-1)到 50%乙醇中孵育 240 小时的 2.39μg l(-1)。PC 瓶中残留的 BPA 浸出量随温度和孵育时间的增加而增加。与从 PC 瓶中观察到的迁移相比，非 PC 婴儿奶瓶和奶瓶衬垫仅显示出痕量的 BPA。由于玻璃奶瓶可能是塑料瓶的潜在替代品，因此还对可溶出的铅和镉进行了测试。未发现玻璃中有可检测到的铅或镉浸出。本研究表明，非 PC 塑料婴儿奶瓶、奶瓶衬垫和玻璃婴儿奶瓶可能是 PC 奶瓶的良好替代品。
