Dehdashti Bahare, Nikaeen Mahnaz, Amin Mohammad Mehdi, Mohammadi Farzaneh
Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Environ Health Insights. 2023 Jan 28;17:11786302231151531. doi: 10.1177/11786302231151531. eCollection 2023.
In recent decades, paying attention to bisphenol A (BPA), as one of the endocrine disruptor compounds, has increased due to its harmful effects. Although, scattered studies have been conducted in order to measure BPA concentration migrated into polymeric baby bottles in different countries of the world, there are no review studies and evaluation with a global perspective in the field of BPA risk. Some of these studies indicated the potential risks and estrogenic effects associated with BPA in babies' daily intake. For this purpose, we reviewed the information on the migration levels of BPA into baby bottles has been reported in 10 countries. The potential risks associated with BPA through the daily intake as well as the estrogenic effect on 3 age groups of babies which include 0 to 6, 6 to 12, and 12 to 24 months were analyzed using the Monte Carlo simulation. Also, kinetic models were applied to predict the kinetics of the migration process of BPA. The median daily intake for 3 age groups was obtained as 191.1, 161.37, and 153.76 µg/kg/day, respectively; which indicated Hazard Index (HI) > 1. The median estrogenic effect for the 3 groups was estimated to be 0.021 ngE/L. The kinetics of contaminant transfer with Polynomial model at 2 temperatures of 24°C and 40°C showed a better fit with = 0.99 and 0.91, respectively. Based on the risk assessment analysis conducted in the present study, the BPA migration in baby bottles appeared to be a health concern for babies. Therefore, it is needed to increase the safety level of bottles for babies as they are sensitive and vulnerable members of every society. Furthermore, in this study, only the investigation of the global situation of BPA in polymeric baby bottles was stated; therefore, more investigation about another potential sources of BPA in food chain is needed.
近几十年来，由于双酚A（BPA）作为内分泌干扰化合物之一具有有害影响，对其的关注度不断提高。尽管世界上不同国家已开展了一些分散的研究来测量迁移到聚合物婴儿奶瓶中的双酚A浓度，但在双酚A风险领域尚无从全球视角进行的综述研究和评估。其中一些研究表明，婴儿日常摄入量中的双酚A存在潜在风险和雌激素效应。为此，我们回顾了10个国家报告的双酚A迁移到婴儿奶瓶中的水平信息。使用蒙特卡罗模拟分析了双酚A通过每日摄入量带来的潜在风险以及对3个年龄组婴儿（包括0至6个月、6至12个月和12至24个月）的雌激素效应。此外，应用动力学模型预测双酚A迁移过程的动力学。3个年龄组的每日摄入量中位数分别为191.1、161.37和153.76μg/kg/天；这表明危害指数（HI）>1。3组的雌激素效应中位数估计为0.021ngE/L。在24°C和40°C这2个温度下，污染物转移的多项式模型动力学分别显示出较好的拟合度，R² = 0.99和0.91。基于本研究进行的风险评估分析，婴儿奶瓶中的双酚A迁移似乎对婴儿健康构成威胁。因此鉴于婴儿是每个社会中敏感且易受伤害的群体，需要提高婴儿奶瓶的安全水平。此外，本研究仅阐述了聚合物婴儿奶瓶中双酚A的全球情况调查；因此，需要对食物链中双酚A的其他潜在来源进行更多调查。
