Berlin Alexander L, Dudelzak Jacob, Hussain Mussarrat, Phelps Robert, Goldberg David J
Skin Laser & Surgery Specialists of NY and NJ, New York, NY 07675, USA.
J Cosmet Laser Ther. 2008 Jun;10(2):76-9. doi: 10.1080/14764170802071165.
The Q-switched Nd:YAG laser was among the first non-ablative lasers to be used. High-fluence photoacoustic Q-switched laser treatments were shown to produce results akin to those seen with some ablative lasers. Previous low-fluence, non-thermal, Q-switched Nd:YAG lasers produced almost no results.
The purpose of this study was to evaluate a new combined photoacoustic/photothermal low-fluence Q-switched Nd:YAG laser in the treatment of facial photodamage.
Ten individuals with photodamaged facial skin were enrolled in the study. Participants underwent six bi-weekly full-face treatments using a Q-switched Nd:YAG laser (RevLite, HOYA ConBio, Freemont, CA, USA) at 1064 nm, with an 8-mm spot size and fluence of 3.2 J/cm(2). Clinical improvement was evaluated through blinded investigator assessment of photographs obtained before and 3 months after the last treatment. Pre-auricular biopsies, performed before and 3 months following the last treatment, were processed for light and electron microscopy and analyzed for evidence of treatment-related changes.
Eight individuals completed the study with no serious or long-term complications. Blinded evaluator assessment documented improvement in a variety of different aspects of photodamaged skin. Biopsy specimens revealed changes consistent with wound repair under light microscopy, while electron microscopy confirmed new collagen deposition.
A novel combined photoacoustic/photothermal Q-switched Nd:YAG laser can be used for non-ablative photorejuvenation. In addition to clinical improvement, histological and ultrastructural changes consistent with new collagen deposition were noted.
调Q开关Nd:YAG激光是最早使用的非剥脱性激光之一。高能量密度的光声调Q激光治疗显示出与某些剥脱性激光相似的效果。以往低能量密度、非热效应的调Q开关Nd:YAG激光几乎没有效果。
本研究旨在评估一种新型的光声/光热联合低能量密度调Q开关Nd:YAG激光对面部光损伤的治疗效果。
10名面部皮肤光损伤患者纳入本研究。参与者使用波长1064nm、光斑直径8mm、能量密度3.2J/cm²的调Q开关Nd:YAG激光（RevLite，HOYA ConBio，美国加利福尼亚州弗里蒙特），每两周进行一次全脸治疗，共治疗6次。通过不知情的研究者对最后一次治疗前及治疗后3个月拍摄的照片进行评估，以评价临床改善情况。在最后一次治疗前及治疗后3个月取耳前组织活检，进行光镜和电镜检查，分析治疗相关变化的证据。
8名患者完成研究，无严重或长期并发症。不知情的评估者评估记录了光损伤皮肤在多个不同方面的改善情况。活检标本在光镜下显示出与伤口修复一致的变化，而电镜证实有新的胶原沉积。
一种新型的光声/光热联合调Q开关Nd:YAG激光可用于非剥脱性光嫩肤。除了临床改善外，还观察到与新胶原沉积一致的组织学和超微结构变化。
