Fridenshteĭn A Ia
Ontogenez. 1991 Mar-Apr;22(2):189-97.
This paper presents literature and author's own data demonstrating that bone marrow contains determined osteogenic precursor cells with high potential to differentiation. They are stem cells of the bone and belong to the stromal cell line of the bone marrow which is histogenetically independent of hemopoietic cells. The paper presents detailed analysis of bone marrow stromal cells (CFUf) as well as of their osteogenic properties and requirements in growth factors. In conclusion mutual growth-stimulating interactions in the system of hemopoietic stromal cells are reviewed.
本文展示了文献及作者自己的数据,证明骨髓中含有具有高分化潜能的定向成骨前体细胞。它们是骨的干细胞,属于骨髓的基质细胞系,在组织发生上独立于造血细胞。本文对骨髓基质细胞(CFUf)及其成骨特性和对生长因子的需求进行了详细分析。最后,对造血基质细胞系统中的相互生长刺激相互作用进行了综述。