Yoshida Hiroki, Miyazaki Yoshiyuki
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Int J Biochem Cell Biol. 2008;40(11):2379-83. doi: 10.1016/j.biocel.2008.05.020. Epub 2008 Jun 8.
Cytokine-mediated immunity plays a crucial role in pathogenesis of various diseases including autoimmune disease. Recently, interleukin 27 was identified, which along with interleukin 23 belongs to the interleukin 12 cytokine family. Interleukin 27 is pivotal for the induction of T helper 1 responses. Recent studies, however, revealed that interleukin 27 has an immunosuppressive property. In interleukin 27 receptor-deficient mice, various pro-inflammatory cytokines were over produced resulting in excess of immune responses. The immunosuppressive effects of interleukin 27 depend on suppression of interleukin 2 production, inhibition of the development of T helper 17 cells (a newly identified inflammatogenic T helper population), and induction of interleukin 10 production. Activation of signal transducers and activators of transcription 1 and 3 is critical in the immunosuppressive function of interleukin 27. Interleukin 27 suppresses some diseases of autoimmune or allergic origin, demonstrating its promising potential in therapy of diseases mediated by inflammatory cytokines.
细胞因子介导的免疫在包括自身免疫性疾病在内的各种疾病的发病机制中起着关键作用。最近，白细胞介素27被发现，它与白细胞介素23同属白细胞介素12细胞因子家族。白细胞介素27对诱导辅助性T细胞1型反应至关重要。然而，最近的研究表明白细胞介素27具有免疫抑制特性。在白细胞介素27受体缺陷小鼠中，各种促炎细胞因子过度产生，导致免疫反应过度。白细胞介素27的免疫抑制作用取决于抑制白细胞介素2的产生、抑制辅助性T细胞17细胞（一种新发现的致炎辅助性T细胞群体）的发育以及诱导白细胞介素10的产生。信号转导子和转录激活子1和3的激活在白细胞介素27的免疫抑制功能中至关重要。白细胞介素27可抑制一些自身免疫性或过敏性疾病，显示出其在治疗炎症细胞因子介导的疾病方面的潜在应用前景。
