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低浓度硝酸银对单纯疱疹病毒的特异性灭活及灭活病毒的生物学活性

Specific inactivation of herpes simplex virus by silver nitrate at low concentrations and biological activities of the inactivated virus.

作者信息

Shimizu F, Shimizu Y, Kumagai K

出版信息

Antimicrob Agents Chemother. 1976 Jul;10(1):57-63. doi: 10.1128/AAC.10.1.57.

Abstract

The infectivities of herpes simplex virus types 1 and 2 were inactivated by silver nitrate at concentrations of 30 muM or less, which did not affect at all the infectivities of hemagglutinating virus of Japan, vesicular stomatitis virus, poliovirus, vaccinia virus, and adenovirus. The inactivated virus retained the capability of adsorbing to the cell, with an adsorption kinetics quite similar to that of intact virus, and of inducing the concanavalin A agglutinability in the infected cells, whereas it lost completely the capability of producing viral antigens and other cytopathic changes.

摘要

1型和2型单纯疱疹病毒的感染性在硝酸银浓度为30μM或更低时被灭活,而这对日本血凝病毒、水疱性口炎病毒、脊髓灰质炎病毒、痘苗病毒和腺病毒的感染性完全没有影响。灭活后的病毒保留了吸附细胞的能力,其吸附动力学与完整病毒非常相似,并且能在受感染细胞中诱导伴刀豆球蛋白A凝集性,然而它完全丧失了产生病毒抗原和其他细胞病变变化的能力。

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