硫酸化多糖是多种包膜病毒的有效且选择性抑制剂，包括单纯疱疹病毒、巨细胞病毒、水疱性口炎病毒和人类免疫缺陷病毒。
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus.
作者信息
Baba M, Snoeck R, Pauwels R, de Clercq E
机构信息
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
出版信息
Antimicrob Agents Chemother. 1988 Nov;32(11):1742-5. doi: 10.1128/AAC.32.11.1742.
Abstract
Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus. They were moderately inhibitory to vaccinia virus but not inhibitory to adenovirus, coxsackievirus, poliovirus, parainfluenza virus, and reovirus. These results indicate that, with the exception of parainfluenza virus, enveloped viruses are specifically susceptible to the inhibitory activity of sulfated polysaccharides.
摘要
几种硫酸化多糖（硫酸葡聚糖、戊聚糖多硫酸盐、岩藻依聚糖和角叉菜胶）被证明是单纯疱疹病毒、人巨细胞病毒、水疱性口炎病毒、辛德毕斯病毒和人类免疫缺陷病毒的有效抑制剂。它们对痘苗病毒有中等程度的抑制作用，但对腺病毒、柯萨奇病毒、脊髓灰质炎病毒、副流感病毒和呼肠孤病毒没有抑制作用。这些结果表明，除副流感病毒外，包膜病毒对硫酸化多糖的抑制活性具有特异性敏感性。
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