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从克罗顿裂叶巴豆（Muell-Arg）乳胶中鉴定次要次生代谢产物并评估其抗氧化活性。

Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activity.

作者信息

De Marino Simona, Gala Fulvio, Zollo Franco, Vitalini Sara, Fico Gelsomina, Visioli Francesco, Iorizzi Maria

机构信息

Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II,Via D. Montesano 49, I-80131 Napoli, Ita.

出版信息

Molecules. 2008 Jun 1;13(6):1219-29. doi: 10.3390/molecules13061219.

DOI:10.3390/molecules13061219
PMID:18596648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6245398/
Abstract

Dragon's blood (Sangre de drago), a viscous red sap derived from Croton lechleri Muell-Arg (Euphorbiaceae), is extensively used by indigenous cultures of the Amazonian basin for its wound healing properties. The aim of this study was to identify the minor secondary metabolites and test the antioxidant activity of this sustance. A bioguided fractionation of the n-hexane, chloroform, n-butanol, and aqueous extracts led to the isolation of 15 compounds: three megastigmanes, four flavan-3-ols, three phenylpropanoids, three lignans, a clerodane, and the alkaloid taspine. In addition to these known molecules, six compounds were isolated and identified for the first time in the latex: blumenol B, blumenol C, 4,5-dihydroblumenol A, erythro-guaiacyl-glyceryl-beta-O-4'- dihydroconiferyl ether, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol and floribundic acid glucoside. Combinations of spectroscopic methods ((1)H-, (13)C- NMR and 2D-NMR experiments), ESI-MS, and literature comparisons were used for compound identification. In vitro antioxidant activities were assessed by DPPH, total antioxidant capacity and lipid peroxidation assays. Flavan-3-ols derivatives (as major phenolic compounds in the latex) exhibited the highest antioxidant activity.

摘要

龙血（Sangre de drago）是一种从巴豆属植物红乌桕（Croton lechleri Muell-Arg，大戟科）中提取的粘性红色汁液，因其具有伤口愈合特性，被亚马逊流域的本土文化广泛使用。本研究的目的是鉴定该物质中的次要次生代谢产物并测试其抗氧化活性。对正己烷、氯仿、正丁醇和水提取物进行生物导向分级分离，得到了15种化合物：三种巨大戟烷型二萜、四种黄烷-3-醇、三种苯丙素类、三种木脂素、一种克罗烷型二萜和生物碱塔斯品碱。除了这些已知分子外，还从乳胶中首次分离并鉴定出六种化合物：二氢豆甾醇B、二氢豆甾醇C、4,5-二氢二氢豆甾醇A、赤型-愈创木基甘油-β-O-4'-二氢松柏醚、2-[4-(3-羟丙基)-2-甲氧基苯氧基]-丙烷-1,3-二醇和多花水仙酸葡萄糖苷。结合光谱方法（(1)H-、(13)C-NMR和二维NMR实验）、电喷雾电离质谱（ESI-MS）以及文献比较来鉴定化合物。通过二苯基苦味酰基自由基（DPPH）、总抗氧化能力和脂质过氧化测定来评估体外抗氧化活性。黄烷-3-醇衍生物（作为乳胶中的主要酚类化合物）表现出最高的抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad8/6245398/f5daba2e46c9/molecules-13-01219-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad8/6245398/f5daba2e46c9/molecules-13-01219-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad8/6245398/f5daba2e46c9/molecules-13-01219-g001a.jpg

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