文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Arf家族GTP负载由正向膜曲率激活并产生正向膜曲率。

Arf family GTP loading is activated by, and generates, positive membrane curvature.

作者信息

Lundmark Richard, Doherty Gary J, Vallis Yvonne, Peter Brian J, McMahon Harvey T

机构信息

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.

出版信息

Biochem J. 2008 Sep 1;414(2):189-94. doi: 10.1042/BJ20081237.

DOI:10.1042/BJ20081237
PMID:18597672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2518064/
Abstract

Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.

摘要

属于Arf（ADP核糖基化因子）家族的小G蛋白通过GTP依赖性募集效应分子，作为众多细胞过程的调节蛋白。在本研究中，我们证明该家族中的蛋白质调节膜曲率，并受膜曲率调节。Arf1和Arf6被证明以膜曲率依赖性方式加载GTP，并通过插入两亲性螺旋来稳定或进一步促进膜曲率的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe2/2518064/cc5798cff8cd/bic054i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe2/2518064/404a1de3777e/bic054i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe2/2518064/cc5798cff8cd/bic054i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe2/2518064/404a1de3777e/bic054i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe2/2518064/cc5798cff8cd/bic054i002.jpg

相似文献

[1]
Arf family GTP loading is activated by, and generates, positive membrane curvature.

Biochem J. 2008-9-1

[2]
Arfs and membrane lipids: sensing, generating and responding to membrane curvature.

Biochem J. 2008-9-1

[3]
EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.

Proc Natl Acad Sci U S A. 2014-8-26

[4]
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.

Nature. 2001-5-10

[5]
Specificities for the small G proteins ARF1 and ARF6 of the guanine nucleotide exchange factors ARNO and EFA6.

J Biol Chem. 2001-7-6

[6]
ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.

PLoS One. 2012-5-30

[7]
Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes.

PLoS One. 2013-4-29

[8]
The structural GDP/GTP cycle of human Arf6.

EMBO Rep. 2001-3

[9]
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.

J Cell Biol. 2000-10-30

[10]
Liposomes in the study of GDP/GTP cycle of Arf and related small G proteins.

Methods Enzymol. 2003

引用本文的文献

[1]
GTP hydrolysis triggers membrane remodeling by AMPH-1.

Sci Adv. 2025-8

[2]
Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells.

Nat Commun. 2025-5-8

[3]
Exploration and analytical techniques for membrane curvature-sensing proteins in bacteria.

J Bacteriol. 2025-4-17

[4]
Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission.

Proc Natl Acad Sci U S A. 2025-3-25

[5]
Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission.

bioRxiv. 2023-12-20

[6]
Membrane Proteins and Membrane Curvature: Mutual Interactions and a Perspective on Disease Treatments.

Biomolecules. 2023-12-11

[7]
Identification of the functional domain of the dense core vesicle biogenesis factor HID-1.

PLoS One. 2023

[8]
RAS GTPases and Interleaflet Coupling in the Plasma Membrane.

Cold Spring Harb Perspect Biol. 2023-9-1

[9]
Generation of nanoscopic membrane curvature for membrane trafficking.

Nat Rev Mol Cell Biol. 2023-1

[10]
Insights into Membrane Curvature Sensing and Membrane Remodeling by Intrinsically Disordered Proteins and Protein Regions.

J Membr Biol. 2022-6

本文引用的文献

[1]
Mediation, modulation, and consequences of membrane-cytoskeleton interactions.

Annu Rev Biophys. 2008

[2]
The hydrophobic insertion mechanism of membrane curvature generation by proteins.

Biophys J. 2008-9

[3]
The small G proteins of the Arf family and their regulators.

Annu Rev Cell Dev Biol. 2007

[4]
ARF proteins: roles in membrane traffic and beyond.

Nat Rev Mol Cell Biol. 2006-5

[5]
Arfs, phosphoinositides and membrane traffic.

Biochem Soc Trans. 2005-12

[6]
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.

Cell. 2005-8-26

[7]
Oligomerization and dissociation of AP-1 adaptors are regulated by cargo signals and by ArfGAP1-induced GTP hydrolysis.

Mol Biol Cell. 2005-10

[8]
Membrane curvature and the control of GTP hydrolysis in Arf1 during COPI vesicle formation.

Biochem Soc Trans. 2005-8

[9]
The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.

J Biol Chem. 2005-6-3

[10]
Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements.

Mol Biol Cell. 2004-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索