Chen Xiaoming, Lu Jianxin, Zhang Yangde, He Jiantai, Guo Xunzhi, Tian Gengyuan, Jin Liqin
Institute of Cellular and Molecular Medicine, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine, Wenzhou Medical College, Wenzhou 325035, PR China.
Int J Biol Macromol. 2008 Oct 1;43(3):252-6. doi: 10.1016/j.ijbiomac.2008.06.004. Epub 2008 Jun 13.
The objective of this study was to evaluate the immunomodulatory effects of the Paecilomyces sinensis polysaccharides (PtP) on the activity of macrophages and human monocytes. A water-soluble polysaccharide, with estimated molecular weight of 2.04x10(4) Da, was isolated from P. sinensis. The results indicate that PtP can increase the activity of LDH and ACP in AMphi and PMphi of rats and human mononuclear cells, and enhance the pinocytic activity of macrophages and TNF-alpha production by human peripheral blood mononuclear cells (PBMC), suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose.
本研究的目的是评估中华拟青霉多糖（PtP）对巨噬细胞和人单核细胞活性的免疫调节作用。从中华拟青霉中分离出一种估计分子量为2.04x10(4) Da的水溶性多糖。结果表明，PtP可增加大鼠肺泡巨噬细胞（AMphi）和腹腔巨噬细胞（PMphi）以及人单核细胞中乳酸脱氢酶（LDH）和酸性磷酸酶（ACP）的活性，并增强巨噬细胞的吞噬活性以及人外周血单核细胞（PBMC）产生肿瘤坏死因子-α（TNF-α）的能力，这表明PtP具有强大的免疫调节特性，有望作为新型潜在免疫刺激剂用于食品和制药领域。
