楝酮A和楝酮B，从毛红椿的嫩枝和树叶中提取的两种新型柠檬苦素。

Chuktabrins A and B, two novel limonoids from the twigs and leaves of Chukrasia tabularis.

作者信息

Zhang Chuan-Rui, Fan Cheng-Qi, Zhang Li, Yang Sheng-Ping, Wu Yan, Lu Yang, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

Org Lett. 2008 Aug 7;10(15):3183-6. doi: 10.1021/ol800885h. Epub 2008 Jul 8.

DOI:10.1021/ol800885h

PMID:18605730

Abstract

Two novel limonoids, chuktabrin A (1), featuring the unique motifs of a 1,3-dioxolan-2-one and a 3,4-dihydro-2 H-pyran, and chuktabrin B (2), possessing an unprecedented polycyclic skeleton, were isolated from Chukrasia tabularis. The structures of 1 and 2 bearing a biosynthetically extended C3 and C2 unit at C-15, respectively, were elucidated on the basis of spectroscopic data, and that of 1 was confirmed by a single-crystal X-ray diffraction.

摘要

从毛麻楝（Chukrasia tabularis）中分离出两种新型柠檬苦素，即具有1,3 - 二氧戊环 - 2 - 酮和3,4 - 二氢 - 2H - 吡喃独特结构单元的楚克拉苦素A（1），以及具有前所未有的多环骨架的楚克拉苦素B（2）。根据光谱数据阐明了化合物1和2的结构，它们分别在C - 15位具有生物合成扩展的C3和C2单元，化合物1的结构通过单晶X射线衍射得以确证。