State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Org Lett. 2012 Sep 7;14(17):4438-41. doi: 10.1021/ol301942v. Epub 2012 Aug 10.
Two new limonoids, chukrasone A (1) incorporating a highly rearranged A/B ring system and chukrasone B (2) possessing the first 16,19-dinor limonoid backbone with an extended C3 unit at C-15, were isolated from Chukrasia tabularis. Their structures were characterized on the basis of detailed spectroscopic analysis. Compounds 1 and 2 exhibited potential inhibition of the delayed rectifier (I(K)) K(+) current.
从苦槛蓝中分离得到两个新的柠檬苦素类化合物，chukrasone A（1）具有高度重排的 A/B 环系统，chukrasone B（2）具有第一个 16,19-二降柠檬苦素骨架，并在 C-15 处扩展了 C3 单元。它们的结构是基于详细的光谱分析来确定的。化合物 1 和 2 表现出对延迟整流器（I（K））K（+）电流的潜在抑制作用。
