Wrighton Katharine H, Dai Fangyan, Feng Xin-Hua
Michael E. DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dev Cell. 2008 Jul;15(1):8-10. doi: 10.1016/j.devcel.2008.06.010.
A recent study from Varelas et al. in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation.
瓦雷拉斯等人近期发表于《自然·细胞生物学》的一项研究揭示了转录调节因子TAZ在转化生长因子β（TGFβ）信号传导中的作用。TAZ不仅将磷酸化的Smad蛋白与转录机制联系起来，对于它们在细胞核内的积累也是必不可少的。
