转化生长因子β领域的新成员：TAZ调控Smad蛋白的核质穿梭
A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling.
作者信息
Wrighton Katharine H, Dai Fangyan, Feng Xin-Hua
机构信息
Michael E. DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Dev Cell. 2008 Jul;15(1):8-10. doi: 10.1016/j.devcel.2008.06.010.
PMID:18606136
Abstract
A recent study from Varelas et al. in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation.
摘要
瓦雷拉斯等人近期发表于《自然·细胞生物学》的一项研究揭示了转录调节因子TAZ在转化生长因子β（TGFβ）信号传导中的作用。TAZ不仅将磷酸化的Smad蛋白与转录机制联系起来，对于它们在细胞核内的积累也是必不可少的。
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