Terry L, Sprinz E, Ribeiro J P
Exercise Research Laboratory, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Int J Sports Med. 1999 Feb;20(2):142-6. doi: 10.1055/s-2007-971108.
HIV-infected individuals are frequently active, but guidelines for exercise in this population lack scientific support, since studies on the effects of exercise training on immunologic variables of HIV-1 positive individuals have shown conflicting results. Exercise capacity, immunologic markers (CD4, CD8 and CD4:CD8 ratio), anthropometric measurements, and depression scores were evaluated to compare the effects of two intensities of aerobic exercise on HIV-1 seropositive individuals. Twenty-one healthy subjects (14 men, 7 women), carriers of the HIV-1 virus (CD4>200 cells x mm(-3)), and inactive for at least 6 months, completed a 12 week exercise training program (36 sessions of 1 h, 3 times per week), in a moderate intensity group (60+/-4% of maximal heart rate) or a high intensity group (84+/-4% of maximal heart rate). Exercise capacity estimated by treadmill time was increased significantly in both moderate intensity (680+/-81 s before; 750+/-151 s after) and high intensity (651+/-122 s before; 841+/-158 s after) groups, but the high intensity group presented a significantly larger increment (p<0.01). There were no significant changes in the immunologic variables, anthropometric measurements or depression scores. Thus, HIV-seropositive individuals that participate in moderate and high intensity exercise programs are able to increase their functional capacity without any detectable changes in immunologic variables, anthropometric measurements or depression scores.
感染艾滋病毒的个体通常较为活跃，但针对该人群的运动指南缺乏科学依据，因为关于运动训练对HIV-1阳性个体免疫变量影响的研究结果相互矛盾。对运动能力、免疫标志物（CD4、CD8和CD4:CD8比值）、人体测量指标和抑郁评分进行评估，以比较两种有氧运动强度对HIV-1血清阳性个体的影响。21名健康受试者（14名男性，7名女性），为HIV-1病毒携带者（CD4>200个细胞×mm(-3)），且至少6个月未进行运动，完成了一项为期12周的运动训练计划（每周3次，每次1小时，共36节），分为中等强度组（最大心率的60±4%）或高强度组（最大心率的84±4%）。通过跑步机运动时间估算的运动能力在中等强度组（运动前680±81秒；运动后750±151秒）和高强度组（运动前651±122秒；运动后841±158秒）均显著提高，但高强度组的增幅明显更大（p<0.01）。免疫变量、人体测量指标或抑郁评分均无显著变化。因此，参与中等强度和高强度运动计划的HIV血清阳性个体能够提高其功能能力，而免疫变量、人体测量指标或抑郁评分均无任何可检测到的变化。
