Jones Raymond, Enogela Ene M, Buchanan Taylor L, Buford Thomas W, Vance David E, Fazeli Pariya L
Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL,USA.
UAB Center for Exercise Medicine, The University of Alabama at Birmingham, Birmingham, AL,USA.
J Phys Act Health. 2023 Jan 14;20(2):149-156. doi: 10.1123/jpah.2022-0304. Print 2023 Feb 1.
Inflammation is an indicator of oxidative stress that may contribute to cardiovascular diseases in older people living with HIV (OPWH). Physical activity (PA) may reduce these biomarkers in OPWH, but little is known about the association of PA with inflammatory and cardiovascular biomarkers. We sought to examine the inflammatory and cardiovascular biomarker correlates of PA and sedentary behavior in OPWH.
We included 101 OPWH with complete assessments of PA, sedentary behavior, and biomarker data to examine the association between the volume of PA and inflammatory and cardiovascular biomarkers.
In this cohort of OPWH (mean age 55.9 y), 68% were male and 83% were African American/Black. Among OPWH, greater volume of PA (ie, walking, moderate, vigorous, and/or total) was associated with lower systolic (P < .05) and diastolic blood pressure (P < .05), pulse pressure (P < .05), and tumor necrosis factor-alpha (P < .05). Greater duration of sitting was associated with greater triglycerides, interleukin-6, and tumor necrosis factor-alpha (P < .05).
Although adherence to regular PA among OPWH is low and sedentary behavior is high, the associations between biomarkers and PA suggest a greater volume of PA could attenuate the inflammatory and cardiovascular derangements experienced by OPWH.
炎症是氧化应激的一个指标，可能导致老年HIV感染者（OPWH）患心血管疾病。体育活动（PA）可能会降低OPWH的这些生物标志物，但关于PA与炎症和心血管生物标志物之间的关联知之甚少。我们试图研究OPWH中PA和久坐行为与炎症及心血管生物标志物的相关性。
我们纳入了101名OPWH，他们对PA、久坐行为和生物标志物数据进行了全面评估，以研究PA量与炎症和心血管生物标志物之间的关联。
在这个OPWH队列（平均年龄55.9岁）中，68%为男性，83%为非裔美国人/黑人。在OPWH中，更多的PA量（即步行、中等强度、剧烈强度和/或总PA量）与较低的收缩压（P < 0.05）、舒张压（P < 0.05）、脉压（P < 0.05）和肿瘤坏死因子-α（P < 0.05）相关。更长的久坐时间与更高的甘油三酯、白细胞介素-6和肿瘤坏死因子-α相关（P < 0.05）。
尽管OPWH中坚持规律PA的比例较低且久坐行为较多，但生物标志物与PA之间的关联表明，更多的PA量可能会减轻OPWH经历的炎症和心血管紊乱。
