Poon Wing Tat, Chau Tai Lin, Lai Chi Kong, Tse Ka Yan, Chan Yiu Cheung, Leung King Sun, Chan Yan Wo
Toxicology Reference Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong, Hong Kong.
Clin Toxicol (Phila). 2008 Nov;46(9):819-22. doi: 10.1080/15563650701739590.
In Hong Kong, Chinese medicine is popular and coexists with orthodox Western medicine. Despite a long history of use, many herbs have not been submitted to rigorous scientific testing and there are reports of hepatotoxicity. We describe a woman who developed acute hepatitis after drinking an herbal remedy containing Teucrium viscidum.
A previously healthy 51-year-old woman was admitted to a regional hospital because of jaundice, with complaints of nausea, vomiting, and tea-colored urine for three days prior to admission. She denied any recent ingestion of known hepatotoxins, but she had consumed an herbal remedy for low back pain for three days before the onset of symptoms. She was icteric and had a serum total bilirubin level of 11.4 mg/dL, alanine aminotransferase of 2620 U/L, aspartate aminotransferase of 1876 U/L, and alkaline phosphatase level of 186 U/L. Discontinuation of the herbal remedy resulted in normalization of the liver enzymes two months later.
This is the first report of hepatitis probably related to use of Teucrium viscidum. The herb is infrequently used in Chinese medicine for treatment of rheumatic and bleeding disorders. T. viscidum contains teucvin, similar to other Teucrium species and is related to T. chamaedrys, commonly known as germander, which is a well documented cause of hepatotoxicity.
Our findings suggest that Teucrium viscidum can cause hepatotoxicity similar to that of germander.
在香港，中医药很受欢迎且与正统西医并存。尽管使用历史悠久，但许多草药尚未经过严格的科学测试，且有肝毒性的报道。我们描述了一名饮用含粘毛香科茶草药后发生急性肝炎的女性。
一名此前健康的51岁女性因黄疸入住一家地区医院，入院前三天有恶心、呕吐和茶色尿的症状。她否认近期摄入任何已知的肝毒素，但在症状出现前三天饮用了一种治疗腰痛的草药。她有黄疸，血清总胆红素水平为11.4mg/dL，丙氨酸转氨酶为2620U/L，天冬氨酸转氨酶为1876U/L，碱性磷酸酶水平为186U/L。停用草药两个月后肝酶恢复正常。
这是首例可能与使用粘毛香科茶有关的肝炎报告。该草药在中医药中很少用于治疗风湿和出血性疾病。粘毛香科茶含有香科茶素，与其他香科茶属植物类似，且与俗称石蚕的石蚕叶香科茶有关，后者是一种有充分文献记载的肝毒性病因。
我们的研究结果表明，粘毛香科茶可导致与石蚕叶香科茶类似的肝毒性。
