Singh Manpreet K, DelBello Melissa P, Fleck David E, Shear Paula K, Strakowski Stephen M
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, Cincinnati, OH, USA.
J Clin Exp Neuropsychol. 2009 Jan;31(1):1-7. doi: 10.1080/13803390801945038. Epub 2008 May 6.
This study examines psychomotor inhibition, sustained attention, and inhibitory attentional control in adolescents (ages 12-18 years) with a nonmanic mood disorder and with a first-degree relative with bipolar I disorder (MD, N = 20) and demographically matched healthy children of parents without any psychiatric disorder (HC, N = 13). MD participants showed abnormal performance in stop signal reaction time and latency (d = 1.28 and 1.64, respectively), sustained attention response bias (d = 0.75), and color naming speed (d = 0.88). The results indicate that MD participants exhibit psychomotor disinhibition, marginal cognitive slowing and cautious response biases, but no formal deficits in sustained or selective attention.
本研究考察了患有非躁狂情绪障碍且有双相I型障碍一级亲属的青少年（12 - 18岁）（情绪障碍组，N = 20）以及父母无任何精神障碍的人口统计学匹配的健康儿童（健康对照组，N = 13）的精神运动抑制、持续注意力和抑制性注意力控制。情绪障碍组参与者在停止信号反应时间和潜伏期（分别为d = 1.28和1.64）、持续注意力反应偏差（d = 0.75）以及颜色命名速度（d = 0.88）方面表现异常。结果表明，情绪障碍组参与者表现出精神运动去抑制、轻微的认知减慢和谨慎的反应偏差，但在持续或选择性注意力方面没有正式的缺陷。
