Sigurdardottir V, Fagerberg B, Wikstrand J, Schmidt C, Hulthe J
The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden.
Scand J Clin Lab Invest. 2008;68(4):292-7. doi: 10.1080/00365510701762723.
The aim of this study was to elucidate the relationship between the echogenicity of carotid artery plaques and the following risk factors: circulating oxLDL, hsCRP, the metabolic syndrome (MetS), and several of the traditional cardiovascular (CV) risk factors.
A cross-sectional population-based study of 513 sixty-one-year-old men. The levels of circulating oxLDL were determined in plasma samples by sandwich ELISA utilizing a specific murine monoclonal antibody (mAb-4E6). High-sensitivity CRP was measured in plasma by ELISA. Plaque occurrence, size and echogenicity were evaluated from B-mode ultrasound registrations in the carotid arteries. Plaque echogenicity was assessed based on a four-graded classification scale.
A higher frequency of echolucent carotid plaques was observed with increasing levels of oxLDL and systolic blood pressure (p = 0.008 and p = 0.041, respectively). Subjects with the MetS had a significantly higher frequency of echogenic plaques than subjects without the MetS (p = 0.009). In a multiple logistic regression analysis, oxLDL turned out to be independently associated with echolucent carotid plaques.
The occurrence of echolucent carotid plaques was associated with oxLDL and systolic blood pressure, and oxLDL was associated with echolucent carotid plaques independently of systolic blood pressure.
本研究旨在阐明颈动脉斑块的回声性与以下危险因素之间的关系：循环氧化型低密度脂蛋白（oxLDL）、高敏C反应蛋白（hsCRP）、代谢综合征（MetS）以及几种传统心血管（CV）危险因素。
一项基于人群的横断面研究，纳入513名61岁男性。采用特异性鼠单克隆抗体（mAb - 4E6）的夹心酶联免疫吸附测定法（ELISA）测定血浆样本中循环oxLDL的水平。采用ELISA法测定血浆中的高敏CRP。通过颈动脉B型超声检查评估斑块的发生情况、大小及回声性。基于四级分类量表评估斑块回声性。
随着oxLDL水平和收缩压的升高，观察到颈动脉低回声斑块的发生率更高（分别为p = 0.008和p = 0.041）。患有MetS的受试者中，回声性斑块的发生率显著高于未患MetS的受试者（p = 0.009）。在多元逻辑回归分析中，oxLDL被证明与颈动脉低回声斑块独立相关。
颈动脉低回声斑块的发生与oxLDL和收缩压有关，且oxLDL与颈动脉低回声斑块的相关性独立于收缩压。
