d'Elia H Forsblad, Rehnberg E, Kvist G, Ericsson A, Konttinen Yt, Mannerkorpi K
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Göteborg University, Sweden.
Scand J Rheumatol. 2008 Jul-Aug;37(4):284-92. doi: 10.1080/03009740801907995.
Primary Sjogren's syndrome (SS) is an autoimmune disease characterized by fatigue. Little is known about the genesis of fatigue. Fatigue is thought to represent a multidimensional concept and it is important to be able to measure it confidently. The aims were to evaluate the reliability and validity of the 20-item Multidimensional Fatigue Inventory (MFI-20) in SS and to search for factors associated with this disabling symptom.
Forty-eight women with primary SS completed the MFI-20 questionnaire. The results were compared with age-matched women with fibromyalgia (FM) and healthy controls. Convergent construct validity was assessed by correlations to a Visual Analogue Scale (VAS) for global fatigue by Spearman's correlation (r(s)). Test-retest reliability was analysed by the intraclass correlation coefficient (ICC) in 28 women. Associations between clinical variables and subscales of the MFI-20 were analysed.
The SS women scored significantly higher in all subscales of the MFI-20 compared to controls but similar to FM. The ICCs were satisfactory, ranging from 0.66 for general fatigue to 0.85 for the total score of MFI-20. All subscales correlated significantly to VAS for global fatigue, general fatigue showing the highest correlation (r(s) = 0.70). The estimated number of hours of sleep/day was significantly associated with many of the fatigue dimensions. All five subscales of the MFI-20 were inversely associated with diastolic blood pressure (BP) and two with systolic BP.
The MFI-20 was found to be a reliable and valid tool for the measurement of fatigue in primary SS. High levels of fatigue were correlated with low BP, suggesting an associated involvement of the autonomic nervous system.
原发性干燥综合征（SS）是一种以疲劳为特征的自身免疫性疾病。关于疲劳的成因知之甚少。疲劳被认为是一个多维度的概念，能够可靠地测量它很重要。本研究旨在评估20项多维疲劳量表（MFI - 20）在SS中的可靠性和有效性，并寻找与这种致残症状相关的因素。
48名原发性SS女性完成了MFI - 20问卷。将结果与年龄匹配的纤维肌痛（FM）女性和健康对照进行比较。通过与视觉模拟量表（VAS）评估的整体疲劳程度进行Spearman相关性分析（r(s)）来评估收敛效度。通过组内相关系数（ICC）分析28名女性的重测信度。分析临床变量与MFI - 20各分量表之间的关联。
与对照组相比，SS女性在MFI - 20的所有分量表上得分显著更高，但与FM组相似。ICC结果令人满意，从一般疲劳的0.66到MFI - 20总分的0.85不等。所有分量表与整体疲劳的VAS均显著相关，一般疲劳显示出最高的相关性（r(s) = 0.70）。估计的每日睡眠时间与许多疲劳维度显著相关。MFI - 20的所有五个分量表均与舒张压（BP）呈负相关，两个与收缩压呈负相关。
发现MFI - 20是测量原发性SS疲劳的可靠且有效的工具。高疲劳水平与低血压相关，提示自主神经系统可能参与其中。
