Gomi K, Kameya T, Tsumuraya M, Shimosato Y, Zeze F, Abe K, Yoneyama T
Cancer. 1976 Oct;38(4):1645-54. doi: 10.1002/1097-0142(197610)38:4<1645::aid-cncr2820380434>3.0.co;2-j.
Two cases of intrathoracic tumor, different in histology and accompanied by hyperamylasemia, were studied ultrastructurally, histochemically, and biochemically. The ultrastructure of the tumor cell cytoplasm showed many zymogen granules in case 1 and smaller cored granules in addition to zymogen granules in case 2. Both tumors contained not only a large amount of amylase, which was electrophoretically of saliva type with three components, but also significant amounts of immunoreactive ACTH and beta-MSH. Starch film and immunofluorescence showed that the tumor cells stored amylase. It was concluded from these findings that the tumor cells ectopically producing amylase, which showed differentiation toward the cells with zymogen production, could differentiate toward the cells of ACTH-MSH system at the same time.
对两例胸腔内肿瘤进行了超微结构、组织化学和生物化学研究，这两例肿瘤组织学不同且伴有高淀粉酶血症。病例1肿瘤细胞胞质超微结构显示有许多酶原颗粒，病例2除酶原颗粒外还有较小的有芯颗粒。两种肿瘤不仅含有大量电泳显示为唾液型且有三种成分的淀粉酶，还含有大量免疫反应性促肾上腺皮质激素（ACTH）和β-促黑素（β-MSH）。淀粉膜和免疫荧光显示肿瘤细胞储存淀粉酶。从这些发现得出结论，异位产生淀粉酶且显示出向产生酶原细胞分化的肿瘤细胞，可同时向促肾上腺皮质激素-促黑素系统的细胞分化。
