Diener H-C, Schneider R, Aicher B
Department of Neurology, University Duisburg-Essen, Essen, Germany.
J Headache Pain. 2008 Aug;9(4):225-31. doi: 10.1007/s10194-008-0046-6. Epub 2008 Jul 10.
There are no reliable data at present on use of analgesics in various countries. We compared per-capita consumption in nine different countries during the period 1986-2005. The per-capita consumption was calculated on the basis of the sales figures of distributors to pharmacies and direct purchases by pharmaceutical companies in a sample of 1,000 pharmacies. The countries studied were: Australia, Austria, Belgium, Canada, France, Germany, Sweden, Switzerland, and the USA. In international comparison Austria, Switzerland, and Germany showed the lowest per-capita consumption of analgesics (approx. 40-50 Standard Units (SU) per capita per year), while in Sweden and France consumption was three times as high. The correlation analysis over the various countries and time points confirmed a significant correlation between use of single analgesics and overall use of analgesics. In Germany, where an allegedly particularly high and constantly rising analgesic use has been discussed controversially (Meiner, Pharm Ind 49:1247-1251, 1987), per-capita consumption of analgesics from 1980 to 2005 remained practically unchanged at approx. 50 SU per capita per year. The prevalence of conditions inducing analgesic use shows appropriate analgesics use on an overall population level.
目前尚无关于各国镇痛药使用情况的可靠数据。我们比较了1986年至2005年期间九个不同国家的人均消费量。人均消费量是根据经销商向药店的销售数据以及制药公司在1000家药店样本中的直接采购量计算得出的。所研究的国家有：澳大利亚、奥地利、比利时、加拿大、法国、德国、瑞典、瑞士和美国。在国际比较中，奥地利、瑞士和德国的镇痛药人均消费量最低（每年人均约40 - 50标准单位（SU）），而瑞典和法国的消费量则是其三倍。对不同国家和时间点的相关性分析证实，单一镇痛药的使用与镇痛药的总体使用之间存在显著相关性。在德国，据称镇痛药的使用特别高且持续上升，这一情况一直存在争议（迈纳，《制药工业》49:1247 - 1251，1987），1980年至2005年期间，镇痛药的人均消费量实际上保持不变，约为每年人均50 SU。导致使用镇痛药的病症患病率表明在总体人群层面上镇痛药的使用是适当的。
