Larsson M, Hägerhed-Engman L, Sigsgaard T, Janson S, Sundell J, Bornehag C-G
Karlstad University, Health and Environmental Sciences, Karlstad, Sweden.
Acta Paediatr. 2008 Sep;97(9):1210-5. doi: 10.1111/j.1651-2227.2008.00910.x.
To estimate the incidence rates for asthma, rhinitis and eczema symptoms and to investigate the importance of different influential factors for the incidence of these symptoms.
The Dampness in Building and Health study commenced in the year 2000 in Värmland, Sweden with a parental questionnaire based on an ISAAC protocol to all children in the age of 1-6 years. Five years later a follow-up questionnaire was sent to the children that were 1-3 years at baseline. In total, 4779 children (response rate = 73%) participated in both surveys and constitute the study population in this cohort study.
The 5-year incidence of doctor-diagnosed asthma was 4.9% (95% CI 4.3-5.3), rhinitis was 5.7% (5.0-6.4) and eczema was 13.4% (12.3-14.5). However, incidence rates strongly depend on the health status of the baseline population. Risk factors for incident asthma were male gender and short period of breast-feeding. Allergic symptoms in parents were also a strong risk factor for incident asthma, as well as for rhinitis and eczema.
When comparing incident rates of asthma between different studies it is important to realize that different definitions of the healthy baseline population will give rise to different incident rates.
评估哮喘、鼻炎和湿疹症状的发病率,并调查不同影响因素对这些症状发病率的重要性。
“建筑中的潮湿与健康”研究于2000年在瑞典韦姆兰开始,针对所有1至6岁儿童,根据国际儿童哮喘和过敏研究(ISAAC)方案设计了一份家长问卷。五年后,向基线时年龄为1至3岁的儿童发送了一份随访问卷。共有4779名儿童(应答率 = 73%)参与了这两项调查,并构成了该队列研究的研究人群。
医生诊断的哮喘5年发病率为4.9%(95%可信区间4.3 - 5.3),鼻炎为5.7%(5.0 - 6.4),湿疹为13.4%(12.3 - 14.5)。然而,发病率很大程度上取决于基线人群的健康状况。哮喘发病的危险因素为男性性别和母乳喂养时间短。父母的过敏症状也是哮喘发病的重要危险因素,对鼻炎和湿疹发病同样如此。
在比较不同研究中哮喘的发病率时,必须认识到对健康基线人群的不同定义会导致不同的发病率。