Cuong Nguyen Manh, Wilhelm Heike, Porzel Andrea, Arnold Norbert, Wessjohann Ludger
Institute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet St., Hanoi, Vietnam 122100.
Nat Prod Res. 2008;22(11):950-4. doi: 10.1080/14786410701650212.
The synthesis of some 1-oxygenated derivatives of murrayafoline A (1) and their antifungal properties is reported. Three derivatives, 1-hydroxy-3-methyl-9H-carbazole (2), 1-(3-methylbut-2-enyloxy)-3-methyl-9H-carbazole (3) and 1-(2,3,4,6,-tetra-O-acetyl-alpha-D-O-glucopyranosyl)-3-methyl-9H-carbazole (4), of murrayafoline A were synthesized. Compounds 1 and 2 exhibit strong fungicidal activity against Cladosporium cucumerinum at the dose of 12.5 microg.
报道了一些默里吖啶A（1）的1-氧化衍生物的合成及其抗真菌特性。合成了默里吖啶A的三种衍生物，即1-羟基-3-甲基-9H-咔唑（2）、1-（3-甲基丁-2-烯氧基）-3-甲基-9H-咔唑（3）和1-（2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基）-3-甲基-9H-咔唑（4）。化合物1和2在12.5微克剂量下对黄瓜枝孢菌表现出很强的杀菌活性。
