九里香甲素的1 - O - 取代衍生物及其抗真菌特性。

1-O-Substituted derivatives of murrayafoline A and their antifungal properties.

作者信息

Cuong Nguyen Manh, Wilhelm Heike, Porzel Andrea, Arnold Norbert, Wessjohann Ludger

机构信息

Institute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet St., Hanoi, Vietnam 122100.

出版信息

Nat Prod Res. 2008;22(11):950-4. doi: 10.1080/14786410701650212.

DOI:10.1080/14786410701650212

PMID:18629709

Abstract

The synthesis of some 1-oxygenated derivatives of murrayafoline A (1) and their antifungal properties is reported. Three derivatives, 1-hydroxy-3-methyl-9H-carbazole (2), 1-(3-methylbut-2-enyloxy)-3-methyl-9H-carbazole (3) and 1-(2,3,4,6,-tetra-O-acetyl-alpha-D-O-glucopyranosyl)-3-methyl-9H-carbazole (4), of murrayafoline A were synthesized. Compounds 1 and 2 exhibit strong fungicidal activity against Cladosporium cucumerinum at the dose of 12.5 microg.

摘要

报道了一些默里吖啶A（1）的1-氧化衍生物的合成及其抗真菌特性。合成了默里吖啶A的三种衍生物，即1-羟基-3-甲基-9H-咔唑（2）、1-（3-甲基丁-2-烯氧基）-3-甲基-9H-咔唑（3）和1-（2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基）-3-甲基-9H-咔唑（4）。化合物1和2在12.5微克剂量下对黄瓜枝孢菌表现出很强的杀菌活性。