Freeman Daniel K, Heine Walter F, Passaglia Christopher L
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Vis Neurosci. 2008 Jul-Aug;25(4):535-48. doi: 10.1017/S095252380808067X. Epub 2008 Jul 18.
Action potentials were recorded from rat retinal ganglion cell fibers in the presence of a uniform field, and the maintained discharge pattern was characterized. Spike trains recorded under ketaminexylazine. The majority of cells had multimodal interval distributions, with the first peak in the range of 25.00.97). Both ON and OFF cells show serial correlations between adjacent interspike intervals, while ON cells also showed second-order correlations. Cells with multimodal interval distribution showed a strong peak at high frequencies in the power spectra in the range of 28.9-41.4 Hz. Oscillations were present under both anesthetic conditions and persisted in the dark at a slightly lower frequency, implying that the oscillations are generated independent of any light stimulus but can be modulated by light level. The oscillation frequency varied slightly between cells of the same type and in the same eye, suggesting that multiple oscillatory generating mechanisms exist within the retina. Cells with high-frequency oscillations were described well by an integrate-and-fire model with the input consisting of Gaussian noise plus a sinusoid where the phase was jittered randomly to account for the bandwidth present in the oscillations.
在均匀场存在的情况下，记录大鼠视网膜神经节细胞纤维的动作电位，并对其持续放电模式进行表征。在氯胺酮-赛拉嗪麻醉下记录的脉冲序列。大多数细胞具有多峰间隔分布，第一个峰值在25.0±0.97范围内。ON细胞和OFF细胞在相邻峰峰间隔之间均表现出序列相关性，而ON细胞还表现出二阶相关性。具有多峰间隔分布的细胞在28.9 - 41.4 Hz范围内的功率谱中高频处有一个强峰。在两种麻醉条件下均存在振荡，且在黑暗中以略低的频率持续存在，这意味着振荡的产生与任何光刺激无关，但可受光照水平调节。同一类型且同一只眼中的细胞之间振荡频率略有变化，表明视网膜内存在多种振荡产生机制。具有高频振荡的细胞可以用一个积分发放模型很好地描述，其输入由高斯噪声加一个正弦波组成，其中相位随机抖动以解释振荡中存在的带宽。
