Vandenabeele Peter, Declercq Wim, Vanden Berghe Tom
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Trends Biochem Sci. 2008 Aug;33(8):352-5. doi: 10.1016/j.tibs.2008.05.007. Epub 2008 Jul 16.
The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.
受体相互作用蛋白1（RIP1）激酶活性对于死亡受体诱导的坏死性细胞死亡是必需的。最近，已证明“坏死抑制因子”通过抑制RIP1激酶活性有效地阻断肿瘤坏死因子诱导的坏死性细胞死亡。这一发现支持了这样的概念，即受体诱导的坏死，就像凋亡一样，是一个可控的细胞过程。此外，坏死抑制因子正成为评估坏死性细胞死亡在实验性疾病模型中作用的重要工具。
