Duncan J I, Horrocks C, Ormerod A D, Powles A V, Whiting P H, Fry L, Thomson A W
Department of Pathology, University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Scotland.
Clin Exp Immunol. 1991 Aug;85(2):293-6. doi: 10.1111/j.1365-2249.1991.tb05721.x.
A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.
开展了一项研究，以量化57例慢性斑块状银屑病患者血清中可溶性白细胞介素-2受体（sIL-2R）水平，并将这些测量结果与疾病活动度以及11例接受环孢素A（CsA）治疗和13例接受补骨脂素加紫外线辐射（PUVA）治疗患者的皮损活检中白细胞介素-2受体阳性（CD25+）淋巴细胞数量相关联。sIL-2R水平与银屑病面积和严重程度指数（PASI）呈强相关。治疗4周后，CsA和PUVA使PASI和sIL-2R水平显著降低至相似程度。尽管大多数接受CsA治疗的活检患者皮损中CD25+细胞减少，但未达到统计学意义；在5例接受PUVA治疗的活检患者中，未观察到对CD25+细胞数量的一致影响。在皮损活检中的CD25+细胞与PASI评分之间发现显著相关性。
