综述：酒精成瘾的神经遗传学研究
Review. Neurogenetic studies of alcohol addiction.
作者信息
Crabbe John C
机构信息
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, VA Medical Center R&D 12, 3710 Southwest US Veterans Hospital Road, Portland, OR 97239, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3201-11. doi: 10.1098/rstb.2008.0101.
Abstract
Neurogenetic studies of alcohol dependence have relied substantially on genetic animal models, particularly rodents. Studies of inbred strains, selectively bred lines and mutants bearing genes whose function has been targeted for over or under expression are reviewed. Studies focused on gene expression changes are the most recent contributors to this literature, and some genetic effects may work through epigenetic mechanisms. In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex.
摘要
酒精依赖的神经遗传学研究在很大程度上依赖于遗传动物模型，尤其是啮齿动物。本文综述了近交系、选择性培育品系以及携带功能被定向过表达或低表达基因的突变体的研究。聚焦于基因表达变化的研究是该领域最新的成果，一些遗传效应可能通过表观遗传机制起作用。在少数情况下，人类的遗传风险与非人类动物模型研究之间揭示出了有趣的相似之处。未来的研究方法可能会越来越复杂。
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