Lindblad William J
Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy & Health Sciences, 179 Longwood Avenue, Boston, MA 02115-5896, USA.
J Biomater Sci Polym Ed. 2008;19(8):1087-96. doi: 10.1163/156856208784909390.
An array of animal models has been described to elucidate wound-healing processes and access the impact of various therapies on healing. However, which model to use for different applications may not be immediately apparent. This article will highlight less frequently used animal models so as to illustrate their utility and increase their use. Selection of an animal model should include consideration of inter-species anatomical and physiological attributes that may confound data interpretation, differences in how different types of wounds heal, and sample size and analytical techniques to be applied. Importantly, the use of human beings should be considered, as techniques have been developed that allow for histological, biochemical and molecular analyses of healing parameters on a scale that could be used in humans.
为了阐明伤口愈合过程并评估各种治疗方法对愈合的影响，人们已经描述了一系列动物模型。然而，对于不同的应用该使用哪种模型可能并非一目了然。本文将重点介绍较少使用的动物模型，以说明它们的实用性并增加其使用频率。选择动物模型应考虑可能混淆数据解释的种间解剖和生理特征、不同类型伤口愈合方式的差异以及要应用的样本量和分析技术。重要的是，应考虑使用人类，因为已经开发出了一些技术，可以在可用于人类的规模上对愈合参数进行组织学、生化和分子分析。
