磷霉素抗性：鼠伤寒沙门氏菌磷酸烯醇式丙酮酸：糖磷酸转移酶基因内部和延伸缺失的选择方法。
Fosfomycin resistance: selection method for internal and extended deletions of the phosphoenolpyruvate:sugar phosphotransferase genes of Salmonella typhimurium.
作者信息
Cordaro J C, Melton T, Stratis J P, Atagün M, Gladding C, Hartman P E, Roseman S
出版信息
J Bacteriol. 1976 Dec;128(3):785-93. doi: 10.1128/jb.128.3.785-793.1976.
Abstract
Selection for resistance to the antibiotic fosfomycin (FOS; L-cis 1,2-epoxypropylphosphonic acid, a structural analogue of phosphoenolpyruvate) was used to isolate mutants carrying internal and extended deletions of varying lengths within the ptsHI operon of Salmonella typhimurium. Strains carrying "tight" ptsI point mutations and all mutants in which some or all of the ptsI gene was deleted were FOS resistant. In contrast, strains carrying ptsH point mutations were sensitive to FOS. Resistance to FOS appeared to result indirectly from catabolite repression of an FOS transport system, probably the sn-glycerol-3-phosphate transport system. Resistant ptsI mutants became sensitive to FOS when grown on D-glucose-6-phosphate, which induces an alternate transport system for FOS, or when grown in the presence of cyclic adenosine 3',5'-monophosphate. A detailed fine-structure map of the pts gene region is presented.
摘要
通过选择对抗生素磷霉素（FOS；L-顺式1,2-环氧丙基膦酸，磷酸烯醇丙酮酸的结构类似物）具有抗性，来分离鼠伤寒沙门氏菌ptsHI操纵子内携带不同长度内部和延伸缺失的突变体。携带“紧密”ptsI点突变的菌株以及ptsI基因部分或全部缺失的所有突变体对FOS具有抗性。相比之下，携带ptsH点突变的菌株对FOS敏感。对FOS的抗性似乎间接源于FOS转运系统（可能是sn-甘油-3-磷酸转运系统）的分解代谢物阻遏。当抗性ptsI突变体在6-磷酸-D-葡萄糖上生长时（6-磷酸-D-葡萄糖可诱导FOS的另一种转运系统），或者在3',5'-环磷酸腺苷存在下生长时，它们对FOS变得敏感。本文给出了pts基因区域的详细精细结构图。
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