Smqnr，嗜麦芽窄食单胞菌中一个新的染色体携带的喹诺酮抗性基因。
Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia.
作者信息
Shimizu Kenichiro, Kikuchi Ken, Sasaki Takashi, Takahashi Namiko, Ohtsuka Masayuki, Ono Yuka, Hiramatsu Keiichi
机构信息
Department of Infection Control Science, Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.
出版信息
Antimicrob Agents Chemother. 2008 Oct;52(10):3823-5. doi: 10.1128/AAC.00026-08. Epub 2008 Jul 21.
Abstract
A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia coli decreased the susceptibilities of the E. coli isolates to several fluoroquinolones.
摘要
对嗜麦芽窄食单胞菌中一个新的染色体携带喹诺酮耐药基因Smqnr进行了表征。该基因存在于模式菌株CCUG 5866中，在24株临床分离株中也被检测到，并表现出一定的等位基因多样性。Smqnr在大肠杆菌中的表达降低了大肠杆菌分离株对几种氟喹诺酮类药物的敏感性。
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