Tsuchihashi Ryota, Sakamoto Seiichi, Kodera Mitsuru, Nohara Toshihiro, Kinjo Junei
Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Fukuoka, 814-0180, Japan.
J Nat Med. 2008 Oct;62(4):456-60. doi: 10.1007/s11418-008-0271-y. Epub 2008 Jul 23.
Intestinal bacteria play an important role for the metabolism of soy isoflavonoids. When soy foods are consumed, the soy isoflavone glucosides are metabolized into their aglycones and the related isoflavonoids by intestinal bacteria. We designed an in vitro microbial metabolic system using 29 commercially available human intestinal bacterial strains and elucidated the metabolism of soy isoflavone glucosides. The strains were classified into three categories, which were 14 facultative anaerobes, 13 obligate anaerobes, and 2 aerobes. Almost all facultative anaerobe strains metabolized soy isoflavone glucosides to their aglycones. The ratio of metabolism from glucoside to aglycone was different in each strain. Contrary to the facultative anaerobes, some of the obligate anaerobes did not metabolize soy isoflavone glucosides at all. Both the aerobic bacteria hardly metabolized soy isoflavone glucosides. The bacterial growth speed might show good correlation to the metabolizing speed of both glucosides. Therefore, the speed of metabolism would be different in each bacterial strain, too.
肠道细菌在大豆异黄酮的代谢过程中发挥着重要作用。食用大豆类食品时，大豆异黄酮糖苷会被肠道细菌代谢为其苷元及相关异黄酮。我们设计了一种体外微生物代谢系统，使用29种市售的人类肠道细菌菌株，并阐明了大豆异黄酮糖苷的代谢情况。这些菌株被分为三类，即14种兼性厌氧菌、13种专性厌氧菌和2种需氧菌。几乎所有兼性厌氧菌菌株都能将大豆异黄酮糖苷代谢为其苷元。每种菌株中糖苷向苷元的代谢比例各不相同。与兼性厌氧菌相反，一些专性厌氧菌根本不代谢大豆异黄酮糖苷。这两种需氧菌几乎都不代谢大豆异黄酮糖苷。细菌的生长速度可能与两种糖苷的代谢速度呈现出良好的相关性。因此，每种细菌菌株的代谢速度也会有所不同。
