Vilberg Kaia L, Rugg Michael D
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA 92697-3800, USA.
Hum Brain Mapp. 2009 May;30(5):1490-501. doi: 10.1002/hbm.20618.
The present study addressed the question whether neural activity in left lateral parietal cortex is modulated by amount of information recollected. In two experiments (one using fMRI and the other ERPs), subjects first studied pairs of pictures presented for either 1 or 6 s. They then performed a standard "Remember/Know" recognition memory test in which the old items comprised one of the pictures from each studied pair. In both experiments, a surprise posttest indicated that subjects recollected more details about the study presentation of the items presented for the longer duration. In the fMRI experiment, recollection- and familiarity-based recognition elicited activity in distinct cortical networks. Additionally, recollection-related activity in left inferior parietal cortex was of greater magnitude for test items presented for 6 s than for 1 s. In the ERP study the "left-parietal old/new effect"-a putative correlate of successful recollection-was likewise modulated by amount of information retrieved. Together, these findings provide further support for dual-process models of recognition memory and add weight to the proposal that retrieval-related activity in left inferior parietal cortex reflects processes supporting the online representation of retrieved episodic information.
本研究探讨了左侧顶叶皮层的神经活动是否会受到回忆信息量的调节。在两项实验中（一项使用功能磁共振成像，另一项使用事件相关电位），受试者首先学习呈现1秒或6秒的图片对。然后，他们进行了标准的“记得/知道”识别记忆测试，其中旧项目包括每个学习对中的一张图片。在两项实验中，一个意外的后测表明，受试者对呈现时间较长的项目的学习呈现回忆了更多细节。在功能磁共振成像实验中，基于回忆和熟悉度的识别在不同的皮层网络中引发了活动。此外，左侧顶下叶皮层中与回忆相关的活动，对于呈现6秒的测试项目而言，其强度大于呈现1秒的项目。在事件相关电位研究中，“左侧顶叶新旧效应”——成功回忆的一个假定相关指标——同样受到检索信息量的调节。这些发现共同为识别记忆的双过程模型提供了进一步支持，并进一步支持了以下观点：左侧顶下叶皮层中与检索相关的活动反映了支持检索到的情景信息在线表征的过程。
