Cheung Winson Y, Brierley James, Mackay Helen J
Department of Medical Oncology and Hematology, University of Toronto, Princess Margaret Hospital, Ontario, Canada.
Clin Colorectal Cancer. 2008 Jul;7(4):280-2. doi: 10.3816/CCC.2008.n.036.
Rectal cancer rarely metastasizes to the thyroid gland. When it does, however, it poses particular problems with regard to diagnosis and management. Case reports to date support a first-line surgical approach alone or in combination with radiation therapy. Despite the use of these treatment modalities, the presence of thyroid metastasis is associated with a very poor prognosis and significant morbidity. Herein, we review the literature and report on 2 cases of rectal carcinoma metastatic to the thyroid gland that were treated with oxaliplatin-containing chemotherapy regimens. In both cases, the patients responded well to combination chemotherapy up front or after previous surgery and chemoradiation. The favorable survival and symptom benefits observed in these patients suggest that combination chemotherapy should be considered in the management of these very rare cases.
直肠癌很少转移至甲状腺。然而，一旦发生转移，在诊断和治疗方面就会出现特殊问题。迄今为止的病例报告支持单独采用一线手术方法或联合放射治疗。尽管使用了这些治疗方式，但甲状腺转移的存在与非常差的预后和显著的发病率相关。在此，我们回顾文献并报告2例接受含奥沙利铂化疗方案治疗的直肠癌转移至甲状腺的病例。在这两例病例中，患者在前期或先前手术及放化疗后对联合化疗反应良好。在这些患者中观察到的良好生存情况和症状改善表明，在处理这些极为罕见的病例时应考虑联合化疗。
