Einfeld S, Hall W, Levy F
Department of Psychiatry, University of Sydney, Australia.
J Abnorm Child Psychol. 1991 Jun;19(3):253-62. doi: 10.1007/BF00911230.
Workers who have claimed an association between Fragile X [fra(x)] Syndrome and Hyperactivity and aggressive behavior have done so despite the lack of controlled studies using standard diagnostic criteria. Accordingly, we provided a controlled test of the hypothesis that individuals with the fra(x) Syndrome are more hyperactive and have more symptoms of aggression than other mentally retarded individuals. The test formed part of a study to assess autistic behavior in fra(x) individuals. A sample of fra(x) individuals was obtained from the register of a clinical genetics unit and individually matched for age, sex, and IQ with mentally retarded individuals selected from assessment centres. Forty-five pairs of fra(x) cases and control individuals were compared on criteria which reflected DSM-III concepts of hyperactivity and on criteria reflecting aggressive behavior. The comparison failed to find a higher prevalence of these symptoms in the fra(x) group. An analysis of the study's statistical power suggested that it is unlikely that the investigation failed to detect a large to medium difference between fra(x) individuals and control individuals in the symptoms investigated.
尽管缺乏使用标准诊断标准的对照研究，但仍有工作人员声称脆性X综合征[fra(x)]与多动及攻击性行为之间存在关联。因此，我们对以下假设进行了对照测试：与其他智力迟钝个体相比，患有fra(x)综合征的个体多动更为明显，且具有更多攻击症状。该测试是一项评估fra(x)个体自闭症行为研究的一部分。从一个临床遗传学单位的登记册中获取了一组fra(x)个体样本，并将其与从评估中心挑选出的智力迟钝个体在年龄、性别和智商方面进行个体匹配。对45对fra(x)病例和对照个体在反映DSM-III多动概念的标准以及反映攻击性行为的标准方面进行了比较。比较结果未能发现fra(x)组中这些症状的患病率更高。对该研究统计效力的分析表明，该调查未能检测到fra(x)个体与对照个体在所研究症状方面存在中等到较大差异的可能性不大。
