Schnyder Svenia, Handschin Christoph
Biozentrum, Div. of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland.
Biozentrum, Div. of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland.
Bone. 2015 Nov;80:115-125. doi: 10.1016/j.bone.2015.02.008.
An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has been linked to an elevated risk for many chronic diseases. The discovery of myokines, hormones produced by skeletal muscle tissue, suggests the possibility that these might be molecular mediators of the whole body effects of exercise originating from contracting muscle fibers. Even though less is known about the sedentary state, the lack of contraction-induced myokines or the production of a distinct set of hormones in the inactive muscle could likewise contribute to pathological consequences in this context. In this review, we try to summarize the most recent developments in the study of muscle as an endocrine organ and speculate about the potential impact on our understanding of exercise and sedentary physiology, respectively. This article is part of a Special Issue entitled "Muscle Bone Interactions".
积极的生活方式对于维持老年健康至关重要；相反，久坐不动与许多慢性疾病风险升高有关。肌动蛋白的发现，即骨骼肌组织产生的激素，提示了这些物质可能是源自收缩肌纤维的运动对全身影响的分子介质。尽管对久坐状态了解较少，但缺乏收缩诱导的肌动蛋白或在不活动肌肉中产生一组独特的激素同样可能在这种情况下导致病理后果。在本综述中，我们试图总结肌肉作为内分泌器官研究的最新进展，并分别推测其对我们理解运动和久坐生理学的潜在影响。本文是名为“肌肉骨骼相互作用”的特刊的一部分。
