Hartl Dominik
Children's Hospital of the Ludwig-Maximilians-University of Munich, Germany.
Med Mycol. 2009;47 Suppl 1:S183-91. doi: 10.1080/13693780802189938. Epub 2008 Jun 10.
Allergic bronchopulmonary aspergillosis (ABPA), a pulmonary hypersensitivity disease mediated by an allergic response to Aspergillus fumigatus (A. fumigatus), occurs preferentially in disease conditions with an impaired pulmonary immunity, especially in cystic fibrosis (CF) and allergic asthma. The pathophysiological mechanisms underlying the link between CF and ABPA are poorly understood. Animal and human data support a critical role for chemokines, especially CCL17 and its receptor CCR4, in ABPA. A summary and discussion of the immunological mechanism involved in the pathogenesis of ABPA with a focus on CF lung disease and the role of chemokines is presented here.
变应性支气管肺曲霉病（ABPA）是一种由对烟曲霉（A. fumigatus）的过敏反应介导的肺部超敏性疾病，优先发生于肺免疫受损的疾病状态，尤其是囊性纤维化（CF）和变应性哮喘。CF与ABPA之间联系的病理生理机制尚不清楚。动物和人体数据支持趋化因子，尤其是CCL17及其受体CCR4在ABPA中起关键作用。本文对ABPA发病机制中涉及的免疫机制进行了总结和讨论，重点关注CF肺部疾病和趋化因子的作用。
