Arrebola J P, Martin-Olmedo P, Fernandez M F, Sanchez-Cantalejo E, Jimenez-Rios J A, Torne P, Porta M, Olea N
Escuela Andaluza de Salud Pública, Cuesta del Observatorio s/n. Campus Universitario de Cartuja s/n, 18080-Granada, Spain.
Environ Int. 2009 Jan;35(1):27-32. doi: 10.1016/j.envint.2008.05.009. Epub 2008 Jul 23.
Hexachlorobenzene (HCB) was measured in adipose tissue intraoperatively collected from 387 subjects over 16 years old undergoing surgery in two hospitals in Granada (Southern Spain). HCB was quantified in 90.7% of subjects. The concentrations and frequencies of HCB were similar to those reported in adipose tissue samples in other recent European studies. Exposure patterns differed between females and males: higher HCB concentrations were found in females than in males (geometric mean 18.3 vs. 6.8 ng/g, p<0.001). The relationship between HCB concentrations and exposure risk factors was assessed by multivariate analysis stratifying by gender. In men, HCB concentrations were predicted (r(2)=0.45) by age, body mass index (BMI), place of residence, smoking, consumption of fish, chicken and cheese, occupation related to agriculture, and family involvement in construction activities. In women, HCB concentrations were predicted (r(2)=0.50) by age, BMI, consumption of milk and cheese, and occupation related to industry. The finding that women had three-fold higher levels of HCB than the men deserves further investigation.
对西班牙南部格拉纳达市两家医院16岁以上接受手术的387名患者术中采集的脂肪组织中的六氯苯（HCB）进行了测量。90.7%的受试者的HCB得到了定量分析。HCB的浓度和频率与近期其他欧洲研究中报道的脂肪组织样本中的浓度和频率相似。女性和男性的接触模式有所不同：女性的HCB浓度高于男性（几何平均值分别为18.3 ng/g和6.8 ng/g，p<0.001）。通过按性别分层的多变量分析评估了HCB浓度与接触风险因素之间的关系。在男性中，HCB浓度可由年龄、体重指数（BMI）、居住地点、吸烟情况、鱼类、鸡肉和奶酪的消费量、与农业相关的职业以及家庭参与建筑活动情况预测（r(2)=0.45）。在女性中，HCB浓度可由年龄、BMI、牛奶和奶酪的消费量以及与工业相关的职业预测（r(2)=0.50）。女性的HCB水平是男性的三倍这一发现值得进一步研究。
