Griffin S M, Lamb P J, Shenfine J, Richardson D L, Karat D, Hayes N
Department of Upper Gastrointestinal Surgery, Northern Oesophago-gastric Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Br J Surg. 2008 Sep;95(9):1115-20. doi: 10.1002/bjs.6294.
The aim of this study was to evaluate the diagnosis, management and outcome of patients with spontaneous rupture of the oesophagus in a single centre.
Between October 1993 and May 2007, 51 consecutive patients with spontaneous oesophageal rupture were evaluated with contrast radiology and flexible endoscopy. Patients with limited contamination who fulfilled specific criteria were managed by a non-operative approach, whereas the remainder underwent thoracotomy.
The median time to diagnosis was 24 (range 4-604) h. Initial diagnosis was by contrast swallow in 18 of 24 patients, computed tomography in 15 of 17 and endoscopy in 18 of 18. There were no deaths among 17 patients who were managed non-operatively with targeted drainage, intravenous antimicrobials, nasogastric decompression and enteral nutrition. Of 31 patients who underwent primary thoracotomy and oesophageal repair (over a Ttube in 29), 11 died in hospital. Three patients could not be resuscitated adequately and did not have surgical intervention.
Spontaneous oesophageal rupture represents a spectrum of disease. Accurate radiological and endoscopic evaluation can identify those suitable for radical non-operative treatment and those who require thoracotomy.
本研究旨在评估单中心食管自发性破裂患者的诊断、治疗及预后情况。
1993年10月至2007年5月期间,对51例连续性食管自发性破裂患者进行了对比放射学检查和纤维内镜检查。符合特定标准且污染较轻的患者采用非手术治疗,其余患者则接受开胸手术。
诊断的中位时间为24(4 - 604)小时。24例患者中有18例最初通过吞咽造影诊断,17例中有15例通过计算机断层扫描诊断,18例中有18例通过内镜检查诊断。17例接受靶向引流、静脉使用抗菌药物、鼻胃管减压和肠内营养非手术治疗的患者无死亡病例。31例接受一期开胸手术和食管修复(29例放置T管)的患者中有11例在医院死亡。3例患者未能得到充分复苏,未接受手术干预。
食管自发性破裂代表了一系列疾病。准确的放射学和内镜评估可以识别出适合非手术根治治疗的患者以及需要开胸手术的患者。