de Lange Jan, van Rijn Rick R, van den Berg Henk, van den Akker Hans P
Department of Oral and Maxillofacial Surgery, Academic Medical Center and Academic Center for Dentistry (ACTA), University of Amsterdam, The Netherlands.
Br J Oral Maxillofac Surg. 2009 Jan;47(1):59-61. doi: 10.1016/j.bjoms.2008.05.013. Epub 2008 Jul 24.
Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. The most common treatment is curettage,which has a high recurrence rate, particularly in more aggressive lesions. Other treatments such as interferon (IFN) and calcitonin have been described. We report a patient with Stickler syndrome and an aggressive central giant cell granuloma in the mandible. Initial treatment with calcitonin was not successful. A combination of IFN and imatinib, given for 9 months, initiated regression of the lesion that continued after treatment had ceased.
中央巨细胞肉芽肿是颌骨的一种良性病变，有时具有局部侵袭性。最常见的治疗方法是刮除术，但其复发率很高，尤其是在侵袭性更强的病变中。其他治疗方法如干扰素（IFN）和降钙素也有相关报道。我们报告了一名患有Stickler综合征且下颌骨有侵袭性中央巨细胞肉芽肿的患者。最初使用降钙素治疗未成功。给予干扰素和伊马替尼联合治疗9个月，病变开始消退，治疗停止后仍在持续。
