Gurney Theresa A, Eisele David W, Orloff Lisa A, Wang Steven J
Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94115, USA.
Otolaryngol Head Neck Surg. 2008 Aug;139(2):262-7. doi: 10.1016/j.otohns.2008.05.024.
Treatment for head and neck cancer, including surgery, radiation, and chemotherapy, can impact quality of life.
Patients seen at an academic institution and treated for oral cavity and oropharyngeal carcinoma were asked to participate. The standardized University of Michigan Head and Neck Specific Quality of Life questionnaire was distributed.
Eighty-seven patients completed the questionnaire. The majority had squamous cell carcinoma (94%), stage III or IV disease (53%), and a history of tobacco or alcohol dependence (59%), and were male (62%). Eighteen percent had free-tissue transfer (fibula free flap in 8% and radial forearm free flap in 10%). Predictors of worse quality of life included advanced stage, gastrostomy-tube dependence, complication, or recurrence.
Stage, gastrostomy-tube dependence, complication, recurrence, and treatment modality influence quality of life. A better understanding of the impact of oral cavity and oropharyngeal cancer treatment on quality of life will enable us to better advise our patients.
头颈癌的治疗，包括手术、放疗和化疗，会影响生活质量。
邀请在一所学术机构就诊并接受口腔和口咽癌治疗的患者参与。发放标准化的密歇根大学头颈特异性生活质量问卷。
87名患者完成了问卷。大多数患者患有鳞状细胞癌（94%）、III期或IV期疾病（53%），有烟草或酒精依赖史（59%），且为男性（62%）。18%的患者接受了游离组织移植（8%为腓骨游离皮瓣，10%为桡侧前臂游离皮瓣）。生活质量较差的预测因素包括晚期、胃造瘘管依赖、并发症或复发。
分期、胃造瘘管依赖、并发症、复发和治疗方式会影响生活质量。更好地了解口腔和口咽癌治疗对生活质量的影响将使我们能够更好地为患者提供建议。
