来自红海海绵软栓海绵的生物活性溴化代谢产物。

Bioactive brominated metabolites from the red sea sponge Suberea mollis.

作者信息

Abou-Shoer Mohamed I, Shaala Lamiaa A, Youssef Diaa T A, Badr Jihan M, Habib Abdel-Azim M

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

出版信息

J Nat Prod. 2008 Aug;71(8):1464-7. doi: 10.1021/np800142n. Epub 2008 Jul 26.

DOI:10.1021/np800142n

PMID:18656986

Abstract

Reinvestigation of the Red Sea sponge Suberea mollis afforded two new bromotyrosine-derived alkaloids, subereamollines A (1) and B (2), two new brominated phenolic compounds, subereaphenols B (7) and C (9), and the known compounds aerothionin (3), homoaerothionin (4), 11,19-dideoxyfistularin-3 (5), aeroplysinin-1 (6), and aeroplysinin-2 (8). The structure determination of the isolated compounds was assigned using one- and two-dimensional NMR spectra and HRFABMS data. The antimicrobial and antioxidant activities of the isolated compounds have been evaluated. Aeroplysinin-1 displayed significant antimicrobial activity against S. aureus, P. aerugenosa, and K. pneumoniae. The isolated compounds were examined for their antioxidant activity using a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) solution-based chemical assay. Among the tested compounds, only subereaphenols B and C displayed a significant effect.

摘要

对红海海绵软栓海绵（Suberea mollis）进行重新研究，得到了两种新的溴酪氨酸衍生生物碱，软栓海绵碱A（1）和B（2），两种新的溴化酚类化合物，软栓海绵酚B（7）和C（9），以及已知化合物气硫素（3）、高同气硫素（4）、11,19 - 二脱氧瘘管素 - 3（5）、气多聚素 - 1（6）和气多聚素 - 2（8）。利用一维和二维核磁共振光谱以及高分辨快原子轰击质谱数据对分离得到的化合物进行结构鉴定。对分离得到的化合物的抗菌和抗氧化活性进行了评估。气多聚素 - 1对金黄色葡萄球菌、铜绿假单胞菌和肺炎克雷伯菌显示出显著的抗菌活性。使用基于2,2 - 二苯基 - 1 - 苦基肼自由基（DPPH）溶液的化学分析法对分离得到的化合物的抗氧化活性进行了检测。在测试的化合物中，只有软栓海绵酚B和C显示出显著效果。