水烟吸食对颊黏膜细胞的遗传毒性作用。
Genotoxic effects of waterpipe smoking on the buccal mucosa cells.
作者信息
El-Setouhy Maged, Loffredo Christopher A, Radwan Ghada, Abdel Rahman Rehab, Mahfouz Eman, Israel Ebenezer, Mohamed Mostafa K, Ayyad Sohair B A
机构信息
Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
Mutat Res. 2008 Aug-Sep;655(1-2):36-40. doi: 10.1016/j.mrgentox.2008.06.014.
Waterpipe smoking is popular in many parts of the world. Micronuclei (MN) evaluation in the exfoliated oral cells of smokers is a non-invasive technique for evaluation of possible tobacco harm. We aimed to assess whether MN levels are higher in waterpipe smokers than in never smokers. We examined oral smears of 128 adult male waterpipe smokers and 78 males who never smoked tobacco in rural Egypt. The total number of MN per 1000 cells per subject, and the number of MN-containing cells per individual were compared. We observed a higher level of total MN in waterpipe smokers (10 +/- 4) than in never smokers (4 +/- 2, p < 0.001). A similar difference was found for the mean number of affected cells per individual (8 +/- 3 vs. 4 +/- 1.62, p < 0.001). MN levels were not significantly dose related. This study is among the first to assess the association between waterpipe smoking and a cytogenetic measure of tobacco harm. The twofold increase in MN level is consistent with previous reports of MN in cigarette smokers. More research is needed to determine if such MN levels are predictive of future health consequences.
水烟吸食在世界许多地区都很流行。对吸烟者脱落口腔细胞中的微核（MN）进行评估是一种用于评估烟草可能危害的非侵入性技术。我们旨在评估水烟吸烟者的微核水平是否高于从不吸烟者。我们检查了埃及农村地区128名成年男性水烟吸烟者和78名从不吸烟男性的口腔涂片。比较了每位受试者每1000个细胞中的微核总数以及每个个体中含有微核的细胞数量。我们观察到，水烟吸烟者的微核总数（10±4）高于从不吸烟者（4±2，p<0.001）。在每个个体受影响细胞的平均数方面也发现了类似差异（8±3对4±1.62，p<0.001）。微核水平与剂量无显著相关性。本研究是最早评估水烟吸食与烟草危害细胞遗传学指标之间关联的研究之一。微核水平增加两倍与之前关于吸烟者微核的报告一致。需要更多研究来确定这种微核水平是否能预测未来的健康后果。
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